PDF(Pubmed)
Abstract：
UNASSIGNED: Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD.
UNASSIGNED: We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis.
UNASSIGNED: Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection).
UNASSIGNED: Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit.
UNASSIGNED: The protocol of this review was registered at PROSPERO: CRD42022366776.
UNASSIGNED: We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis.
UNASSIGNED: Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection).
UNASSIGNED: Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit.
UNASSIGNED: The protocol of this review was registered at PROSPERO: CRD42022366776.
摘要：
■病毒后嗅觉功能障碍（PVOD）是长发COVID的常见症状，缺乏有效的治疗方法。中药（TCM）据称可有效治疗嗅觉功能障碍，但是证据尚未得到严格评估。我们进行了系统评价中药治疗PVOD的有效性和安全性。
■我们搜索了8个数据库，以确定有关中医治疗PVOD的临床对照研究。使用偏倚工具和GRADE的Cochrane风险评估证据质量。风险比（RR），平均差异(MD)，和95%置信区间(CI)，用于效果估计，RevMan5.4.1用于数据分析。
■六项随机对照试验（RCT）（545名参与者），两项非随机对照试验（非随机对照试验）（112名参与者），纳入1项回顾性队列研究(30名参与者).纳入研究的总体质量较低。针灸(n=8)和穴位注射(n=3)是中医治疗的主要方法。5项随机对照试验在中药组有较好的疗效。四项试验使用针灸，和三个试验使用穴位注射。两项非RCT和一项队列研究的结果无统计学意义。两项试验报告了轻度至中度不良事件（针刺或穴位注射引起的疼痛和短暂晕厥）。
■有限的证据集中在针灸和穴位注射治疗PVOD上，表明针灸和穴位注射可能有效改善PVOD。更多精心设计的试验应该集中在针灸上，以确认其益处。
■本次审查的方案在PROSPERO注册：CRD42022366776。
■我们搜索了8个数据库，以确定有关中医治疗PVOD的临床对照研究。使用偏倚工具和GRADE的Cochrane风险评估证据质量。风险比（RR），平均差异(MD)，和95%置信区间(CI)，用于效果估计，RevMan5.4.1用于数据分析。
■六项随机对照试验（RCT）（545名参与者），两项非随机对照试验（非随机对照试验）（112名参与者），纳入1项回顾性队列研究(30名参与者).纳入研究的总体质量较低。针灸(n=8)和穴位注射(n=3)是中医治疗的主要方法。5项随机对照试验在中药组有较好的疗效。四项试验使用针灸，和三个试验使用穴位注射。两项非RCT和一项队列研究的结果无统计学意义。两项试验报告了轻度至中度不良事件（针刺或穴位注射引起的疼痛和短暂晕厥）。
■有限的证据集中在针灸和穴位注射治疗PVOD上，表明针灸和穴位注射可能有效改善PVOD。更多精心设计的试验应该集中在针灸上，以确认其益处。
■本次审查的方案在PROSPERO注册：CRD42022366776。
