PDF(Pubmed)
Abstract：
Cellular senescence is the state in which cells undergo irreversible cell cycle arrest and acquire diverse phenotypes. It has been linked to chronic inflammation and fibrosis in various organs as well as to individual aging. Therefore, eliminating senescent cells has emerged as a potential target for extending healthy lifespans. Cellular senescence plays a beneficial role in many biological processes, including embryonic development, wound healing, and tissue regeneration, which is mediated by the activation of stem cells. Therefore, a comprehensive understanding of cellular senescence, including both its beneficial and detrimental effects, is critical for developing safe and effective treatment strategies to target senescent cells. This review provides an overview of the biological and pathological roles of cellular senescence, with a particular focus on its beneficial or detrimental functions among its various roles.
摘要：
细胞衰老是细胞经历不可逆的细胞周期停滞并获得不同表型的状态。它与各种器官的慢性炎症和纤维化以及个体衰老有关。因此,消除衰老细胞已成为延长健康寿命的潜在目标。细胞衰老在许多生物过程中起着有益的作用，包括胚胎发育,伤口愈合，和组织再生，这是由干细胞的激活介导的。因此,全面了解细胞衰老，包括其有益和有害的影响，对于开发针对衰老细胞的安全有效的治疗策略至关重要。本文综述了细胞衰老的生物学和病理学作用。特别关注其各种角色中的有益或有害功能。
