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Abstract：
Staphylococcus aureus is a pathogen with high epidemic potential frequently involved in nosocomials and communities infections. The pathogenicity of Staphylococcus aureus is due to both its ability to resist antibiotics and to Produce toxins. This work aims at studying the resistance and Molecular Epidemiology of Staphylococcus aureus. Antibiotic susceptibility of the 70 strains isolates of Staphylococcus aureus was determined by agar diffusion while Multiplex PCR and MLST were used to search toxin-coding genes and MRSA typing, respectively. 14.28% of isolates were multidrug resistant. Staphylococcus aureus showed high susceptibility to aminoglycoside and Macrolides familly. lukS-PV/lukF-PV and sea genes were detected in 45% and 3% of Staphylococcus aureus respectively. Ten (10) sequence types including ST5710, ST2430, ST5289, ST5786, ST6942, ST6943, ST6944, ST6945, ST6946, ST6947 have been reported. The study showed a diversity of antibiotic resistance phenotypes and a great diversity of MRSA clones causing infections.
摘要：
金黄色葡萄球菌是一种具有高流行潜力的病原体，经常参与医院和社区感染。金黄色葡萄球菌的致病性是由于其抵抗抗生素和产生毒素的能力。本文旨在研究金黄色葡萄球菌的耐药性和分子流行病学。通过琼脂扩散测定70株金黄色葡萄球菌的抗生素敏感性，同时使用多重PCR和MLST搜索毒素编码基因和MRSA分型。分别。14.28%的分离株存在多重耐药。金黄色葡萄球菌对氨基糖苷类和大环内酯类的敏感性较高。在45％和3％的金黄色葡萄球菌中分别检测到lukS-PV/lukF-PV和sea基因。已经报道了十(10)种序列类型,包括ST5710、ST2430、ST5289、ST5786、ST6942、ST6943、ST6944、ST6945、ST6946、ST6947。该研究表明抗生素抗性表型的多样性和引起感染的MRSA克隆的巨大多样性。
