PDF(Pubmed)
Abstract：
Chronic psychological stress is a critical factor for neurological complications like anxiety disorders, dementia, and depression. Our previous results show that chronic restraint stress causes cognitive deficits and mood dysregulation by inducing autophagic death of adult hippocampal neural stem cells (NSCs). However, it is unknown whether other models of psychological stress also induce autophagic death of adult hippocampal NSCs. Here, we show that chronic unpredictable stress (CUS) for 10 days impaired memory function and increased anxiety in mice. Immunohistochemical staining with SOX2 and KI67 revealed a significant reduction in the number of NSCs in the hippocampus following exposure to CUS. However, these deficits were prevented by NSC-specific, inducible conditional deletion of Atg7. These findings suggest that autophagic death of adult hippocampal NSCs is a critical pathogenic mechanism underlying stress-induced brain disorders.
摘要：
慢性心理压力是焦虑症等神经系统并发症的关键因素，痴呆症,和抑郁症。我们先前的结果表明，慢性束缚应激通过诱导成年海马神经干细胞（NSCs）的自噬死亡而导致认知缺陷和情绪失调。然而,目前尚不清楚其他心理应激模型是否也能诱导成年海马神经干细胞的自噬性死亡。这里,我们表明，慢性不可预知应激（CUS）10天损害小鼠的记忆功能和增加的焦虑。用SOX2和KI67进行的免疫组织化学染色显示，暴露于CUS后海马中的NSC数量显着减少。然而,这些赤字是由特定的国家安全委员会防止的，Atg7的诱导型条件性缺失。这些发现表明，成年海马神经干细胞的自噬性死亡是应激诱导的脑部疾病的重要致病机制。
