PDF(Pubmed)
Abstract：
Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here, we present a translational patch material that exhibits instant adhesion to tissues (2.5-fold stronger than Tisseel, an FDA-approved fibrin glue), ultra-stretchability (stretching to >300% its original length without losing elasticity), compatibility with rapid photo-projection (<2 min fabrication time/patch), and ability to deliver therapeutics. Using our established procedures for the in silico design and optimization of anisotropic-auxetic patches, we created next-generation patches for instant attachment to tissues while conforming to a broad range of organ mechanics ex vivo and in vivo. Patches coated with extracellular vesicles derived from mesenchymal stem cells demonstrate robust wound healing capability in vivo without inducing a foreign body response and without the need for patch removal that can cause pain and bleeding. We further demonstrate a single material-based, void-filling auxetic patch designed for the treatment of lung puncture wounds.
摘要：
生物粘附材料和贴片是有希望的外科缝合线和U形钉的替代品。然而,许多现有的生物粘合剂不满足当前外科手术和干预的功能要求。这里,我们提出了一种平移贴片材料，它表现出对组织的即时粘附力（比蒂塞尔强2.5倍，FDA批准的纤维蛋白胶)，超拉伸性（拉伸至原始长度的300％而不失去弹性），与快速照片投影的兼容性（<2分钟制造时间/补丁），和提供治疗的能力。使用我们建立的各向异性拉胀贴片的计算机设计和优化程序，我们创造了下一代贴剂，用于即时附着到组织上，同时符合广泛的离体和体内器官力学。用源自间充质干细胞的细胞外囊泡涂覆的贴片在体内表现出强大的伤口愈合能力,而不诱导异物反应,并且不需要可引起疼痛和出血的贴片去除。我们进一步展示了一种基于单一材料的，设计用于治疗肺穿刺伤口的空隙填充拉胀补片。
