Abstract：
Only 0.016 % of all known natural products contain an aziridine ring, but this unique structural feature imparts high reactivity and cytotoxicity to the compounds in which it is found. Until 2021, no naturally occurring aziridine-forming enzymes had been identified. Since 2021, the biosynthetic enzymes for ~10 % of known aziridine containing natural products have been identified and characterized. This article describes the recent advances in our understanding of enzyme-catalyzed aziridine formation in the context of historical methods for aziridine formation through synthetic chemistry.
摘要：
所有已知的天然产物中只有0.016%含有氮丙啶环,但是这种独特的结构特征赋予了发现它的化合物高反应性和细胞毒性。直到2021年，还没有发现天然存在的氮杂环丁烷形成酶。自2021年以来，已鉴定并表征了约10％已知的含氮丙啶天然产物的生物合成酶。本文介绍了在通过合成化学形成氮丙啶的历史手段的背景下，我们对酶催化的氮丙啶形成的理解的最新进展。
