Abstract：
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. However, there is no data on AF inpatient management strategies and clinical outcomes in Syria.
OBJECTIVE: The study aims were to review the inpatient management of patients with AF and assess cardiovascular (CV) mortality in a tertiary cardiology centre in Latakia, Syria.
METHODS: A single-centre retrospective observational cohort study was conducted at Tishreen\'s University Hospital, Latakia, Syria, from June 2021 to June 2023. Patients ≥16 years of age presenting and being treated for AF as the primary diagnosis with or without a thromboembolic event were included. Medical records were examined for patients\' demographics, laboratory results, treatment plans and inpatient details. Studied outcomes include inpatient all-cause and CV mortality, ischemic and bleeding events, and conversion to sinus rhythm (SR).
RESULTS: The study included 596 patients. The median age was 58, and 61% were males. 121 patients (20.3%) were known to have AF. A rhythm control strategy was pursued in 39% of patients. Ischemic and bleeding events occurred in 62 (11%) and 12 (2%), respectively. CV and all-cause mortality occurred in 28 (4.7%) and 31 patients (5%), respectively. The presence of valvular heart disease (VHD) (adjusted odds ratio (aOR) = 9.1, 95% confidence interval (CI): 1.7 to 55.1, p < .001), thyroid disease (aOR: 9.7, 95% CI = 1.2 to 91.6, p < .001) and chronic obstructive pulmonary disease (COPD) (aOR: 82, 95% CI: 12.7 to 71, p < .001) were independent risk factors of increased CV inpatient mortality.
CONCLUSIONS: Syrian inpatients admitted with AF in Latakia are relatively younger than those in other countries. Active thyroid disease, COPD and VHD were independent risk factors of inpatient CV mortality with AF.
OBJECTIVE: The study aims were to review the inpatient management of patients with AF and assess cardiovascular (CV) mortality in a tertiary cardiology centre in Latakia, Syria.
METHODS: A single-centre retrospective observational cohort study was conducted at Tishreen\'s University Hospital, Latakia, Syria, from June 2021 to June 2023. Patients ≥16 years of age presenting and being treated for AF as the primary diagnosis with or without a thromboembolic event were included. Medical records were examined for patients\' demographics, laboratory results, treatment plans and inpatient details. Studied outcomes include inpatient all-cause and CV mortality, ischemic and bleeding events, and conversion to sinus rhythm (SR).
RESULTS: The study included 596 patients. The median age was 58, and 61% were males. 121 patients (20.3%) were known to have AF. A rhythm control strategy was pursued in 39% of patients. Ischemic and bleeding events occurred in 62 (11%) and 12 (2%), respectively. CV and all-cause mortality occurred in 28 (4.7%) and 31 patients (5%), respectively. The presence of valvular heart disease (VHD) (adjusted odds ratio (aOR) = 9.1, 95% confidence interval (CI): 1.7 to 55.1, p < .001), thyroid disease (aOR: 9.7, 95% CI = 1.2 to 91.6, p < .001) and chronic obstructive pulmonary disease (COPD) (aOR: 82, 95% CI: 12.7 to 71, p < .001) were independent risk factors of increased CV inpatient mortality.
CONCLUSIONS: Syrian inpatients admitted with AF in Latakia are relatively younger than those in other countries. Active thyroid disease, COPD and VHD were independent risk factors of inpatient CV mortality with AF.
摘要：
背景：心房颤动（AF）是全球最常见的持续性心律失常。然而,没有关于叙利亚房颤住院管理策略和临床结局的数据.
目的：本研究旨在评估拉塔基亚三级心脏病中心房颤患者的住院管理情况，并评估心血管疾病（CV）死亡率，叙利亚。
方法：在Tishreen大学医院进行了一项单中心回顾性观察性队列研究，拉塔基亚,叙利亚,从2021年6月到2023年6月。纳入年龄≥16岁的患者，以房颤为主要诊断，有或没有血栓栓塞事件。医疗记录检查了患者的人口统计学，实验室结果,治疗计划和住院细节。研究结果包括住院全因死亡率和心血管死亡率，缺血和出血事件，和转换为窦性心律（SR）。
结果：该研究包括596名患者。中位年龄为58岁，61%为男性。已知121例患者（20.3%）患有房颤。39%的患者采用了节律控制策略。62例（11%）和12例（2%）发生缺血和出血事件，分别。CV和全因死亡率分别为28例（4.7%）和31例（5%），分别。瓣膜性心脏病（VHD）的存在（调整比值比（aOR）=9.1，95％置信区间（CI）：1.7至55.1，p<.001），甲状腺疾病(aOR:9.7,95%CI=1.2~91.6,p<.001)和慢性阻塞性肺疾病(COPD)(aOR:82,95%CI:12.7~71,p<.001)是CV住院患者死亡率增加的独立危险因素。
结论：拉塔基亚的叙利亚房颤住院患者相对年轻。活动性甲状腺疾病，COPD和VHD是房颤住院患者CV死亡的独立危险因素。
目的：本研究旨在评估拉塔基亚三级心脏病中心房颤患者的住院管理情况，并评估心血管疾病（CV）死亡率，叙利亚。
方法：在Tishreen大学医院进行了一项单中心回顾性观察性队列研究，拉塔基亚,叙利亚,从2021年6月到2023年6月。纳入年龄≥16岁的患者，以房颤为主要诊断，有或没有血栓栓塞事件。医疗记录检查了患者的人口统计学，实验室结果,治疗计划和住院细节。研究结果包括住院全因死亡率和心血管死亡率，缺血和出血事件，和转换为窦性心律（SR）。
结果：该研究包括596名患者。中位年龄为58岁，61%为男性。已知121例患者（20.3%）患有房颤。39%的患者采用了节律控制策略。62例（11%）和12例（2%）发生缺血和出血事件，分别。CV和全因死亡率分别为28例（4.7%）和31例（5%），分别。瓣膜性心脏病（VHD）的存在（调整比值比（aOR）=9.1，95％置信区间（CI）：1.7至55.1，p<.001），甲状腺疾病(aOR:9.7,95%CI=1.2~91.6,p<.001)和慢性阻塞性肺疾病(COPD)(aOR:82,95%CI:12.7~71,p<.001)是CV住院患者死亡率增加的独立危险因素。
结论：拉塔基亚的叙利亚房颤住院患者相对年轻。活动性甲状腺疾病，COPD和VHD是房颤住院患者CV死亡的独立危险因素。
