Abstract：
The somatosensory cortex is a brain region responsible for receiving and processing sensory information from across the body and is structurally and functionally heterogeneous. Since the chemoarchitectonic segregation of the cerebral cortex can be revealed by transmitter receptor distribution patterns, by using a quantitative multireceptor architectonical analysis, we determined the number and extent of distinct areas of the macaque somatosensory cortex. We identified three architectonically distinct cortical entities within the primary somatosensory cortex (i.e., 3bm, 3bli, 3ble), four within the anterior parietal cortex (i.e., 3am, 3al, 1 and 2) and six subdivisions (i.e., S2l, S2m, PVl, PVm, PRl and PRm) within the lateral fissure. We provide an ultra-high resolution 3D atlas of macaque somatosensory areas in stereotaxic space, which integrates cyto- and receptor architectonic features of identified areas. Multivariate analyses of the receptor fingerprints revealed four clusters of identified areas based on the degree of (dis)similarity of their receptor architecture. Each of these clusters can be associated with distinct levels of somatosensory processing, further demonstrating that the functional segregation of cortical areas is underpinned by differences in their molecular organization.
摘要：
体感皮层是负责接收和处理来自整个身体的感觉信息的大脑区域,并且在结构和功能上是异质的。由于可以通过递质受体分布模式揭示大脑皮层的化学结构分离，通过使用定量多受体结构分析，我们确定了猕猴体感皮层不同区域的数量和范围。我们在初级体感皮层中确定了三个结构上不同的皮层实体(即，3bm,3bli,3ble),前顶叶皮层内的四个(即，凌晨3点，3al,1和2)和六个细分(即，S2l,S2m,PVl,PVm,PRl和PRm）在侧裂内。我们在立体定位空间中提供了猕猴体感区域的超高分辨率3D图谱，它整合了已识别区域的细胞和受体结构特征。受体指纹图谱的多变量分析显示，基于其受体结构的（非）相似性程度，已识别区域的四个簇。这些集群中的每一个都可以与不同级别的体感处理相关联，进一步证明皮质区域的功能分离是由其分子组织的差异支撑的。
