In women with uncomplicated UTIs, gepotidacin was noninferior to nitrofurantoin for therapeutic response at 10 to 13 d.

在没有复杂 UTI 的女性中 ，在 10 至 13 d 的治疗反应中 ， 吉泊妥辛不劣于呋喃妥因。

• 影响指数: 51.598
• 发表时间: 2024 Jun 4
• 来源期刊: Ann Intern Med
• DOI: 10.7326/ANNALS-24-00438-JC
• PMID: 38830223
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Granwehr B

Mesh: Adult; Female; Humans; Middle Aged; Acenaphthenes; Anti-Bacterial Agents / therapeutic use administration & dosage; Anti-Infective Agents, Urinary / therapeutic use; Double-Blind Method; Heterocyclic Compounds, 3-Ring / therapeutic use; Nitrofurantoin / therapeutic use; Urinary Tract Infections / drug therapy; Randomized Controlled Trials as Topic; Clinical Trials, Phase III as Topic

Abstract

UNASSIGNED: Wagenlehner F, Perry CR, Hooton TM, et al. Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials. Lancet. 2024;403:741-755. 38342126.

摘要

■WagenlehnerF,佩里CR,HootonTM,etal.单纯性尿路感染（EAGLE-2和EAGLE-3）患者口服吉泊妥因与呋喃妥因的比较：两种随机，控制,双盲,双假人,第三阶段，非劣效性试验。柳叶刀.2024；403：741-755。38342126。