从 ALK 阳性肺腺癌衍生的肿瘤样体内转化为鳞状细胞癌。
关键词: ALK fusion genes Adenosquamous carcinoma Lung cancer Preclinical cancer model Tumoroids
Mesh : Humans Lung Neoplasms / genetics pathology drug therapy Anaplastic Lymphoma Kinase / genetics metabolism Carcinoma, Squamous Cell / genetics pathology Oncogene Proteins, Fusion / genetics metabolism Mutation Protein Kinase Inhibitors / pharmacology therapeutic use Animals Cell Transformation, Neoplastic / genetics Adenocarcinoma / genetics pathology Tumor Suppressor Protein p53 / genetics metabolism Adenocarcinoma of Lung / genetics pathology Crizotinib / pharmacology Cell Line, Tumor Carcinoma, Non-Small-Cell Lung / genetics pathology
来 源:
DOI:10.1007/s13577-024-01085-8
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