Abstract：
Dry skin is a common dermatological condition that frequently affects the elderly. A contributing cause to dry skin is a reduced concentration of hyaluronic acid (HA) in both the epidermis and dermis. The effectiveness of moisturizer containing HA as a therapy for dry skin is impacted by its specific molecular weight. Low molecular weight HA (LMWHA) is believed to be more effective in replenishing skin hydration in aging skin compared to High Molecular Weight HA (HMWHA) due to its ability to penetrate the stratum corneum. However, there is a lack of clinical research supporting this claim. A double-blind, randomized controlled trial was conducted on 36 residents of a nursing home in Jakarta. The participants, aged between 60 and 80 years, had been diagnosed with dry skin. Each test subject was administered three distinct, randomized moisturizing lotions (LMWHA, HMWHA, or vehicle), to be topically applied to three separate sites on the leg. Skin capacitance (SCap), transepidermal water loss (TEWL), and specified symptom sum score (SRRC) were measured at weeks 0, 2, and 4. After four weeks of therapy, area that was treated with LMWHA showed greater SCap values compared to the area treated with HMWHA (56.37 AU vs. 52.37 AU, p = 0.004) and vehicle (56.37 AU vs. 49.01 AU, p < 0.001). All groups did not show any significant differences in TEWL and SRRC scores. No side effects were found in all groups. The application of a moisturizer containing LMWHA to the dry skin of elderly resulted in significant improvements in skin hydration compared to moisturizers containing HMWHA and vehicle. Furthermore, these moisturizers demonstrated similar safety in treating dry skin in the elderly. ClinicalTrials.gov Identifier NCT06178367, https://clinicaltrials.gov/study/NCT06178367 .
摘要：
皮肤干燥是一种常见的皮肤病，经常影响老年人。造成皮肤干燥的原因是表皮和真皮中透明质酸(HA)的浓度降低。含有HA的保湿剂作为治疗干性皮肤的有效性受到其特定分子量的影响。与高分子量HA(HMWHA)相比,低分子量HA(LMWHA)由于其穿透角质层的能力而被认为在补充老化皮肤中的皮肤水合作用方面更有效。然而,缺乏支持这一说法的临床研究。双盲，在雅加达一家疗养院的36名居民中进行了随机对照试验.参与者,年龄在60至80岁之间，被诊断为皮肤干燥。每个测试对象被给予三个不同的，随机保湿乳液(LMWHA，HMWHA,或车辆)，局部应用于腿上的三个独立部位。皮肤电容(SCap),经皮水分流失（TEWL），并在第0、2和4周测量特定症状总和评分（SRRC）。经过四周的治疗,与用HMWHA治疗的区域相比，用LMWHA治疗的区域显示出更大的SCap值（56.37AUvs.52.37AU,p=0.004）和车辆（56.37AUvs.49.01AU,p<0.001)。所有组的TEWL和SRRC评分均未显示任何显着差异。所有组均未发现副作用。与含有HMWHA和赋形剂的保湿剂相比,将含有LMWHA的保湿剂应用于老年人的干燥皮肤导致皮肤水合作用的显著改善。此外，这些保湿剂在治疗老年人皮肤干燥方面表现出类似的安全性。ClinicalTrials.gov标识符NCT06178367,https://clinicaltrials.gov/study/NCT06178367.
