Abstract：
UNASSIGNED: To examine the safety of cardiorespiratory fitness (CRF) assessment and training in the early sub-acute phase of recovery (≤3 months) following moderate-to-extremely severe traumatic brain injury (TBI).
UNASSIGNED: A systematic review was completed in accordance with the PRISMA guidelines. Studies investigating adults and adolescents ≥15 years with moderate-to-extremely severe TBI were considered for inclusion. The methodological quality of the included studies was evaluated according to the McMaster Guidelines for Critical Review Form - Quantitative Studies.
UNASSIGNED: Eleven studies with a total of 380 participants were included in the review. Adverse events (AEs) and symptom monitoring were poorly reported. Only four studies reported on the occurrence of AEs, with a total of eight AEs reported. Three of the reported AEs were concussion-like symptoms with no further exercise-induced symptom exacerbation reported. No serious AEs were reported.
UNASSIGNED: There is no evidence to suggest that CRF assessment and training is unsafe in the early sub-acute phase of recovery following moderate-to-extremely severe TBI. However, despite the low AE and symptom exacerbation rates identified, a timeframe for safe commencement was unable to be established due to poor reporting and/or monitoring of exercise-induced symptoms and AEs in the current literature.
UNASSIGNED: A systematic review was completed in accordance with the PRISMA guidelines. Studies investigating adults and adolescents ≥15 years with moderate-to-extremely severe TBI were considered for inclusion. The methodological quality of the included studies was evaluated according to the McMaster Guidelines for Critical Review Form - Quantitative Studies.
UNASSIGNED: Eleven studies with a total of 380 participants were included in the review. Adverse events (AEs) and symptom monitoring were poorly reported. Only four studies reported on the occurrence of AEs, with a total of eight AEs reported. Three of the reported AEs were concussion-like symptoms with no further exercise-induced symptom exacerbation reported. No serious AEs were reported.
UNASSIGNED: There is no evidence to suggest that CRF assessment and training is unsafe in the early sub-acute phase of recovery following moderate-to-extremely severe TBI. However, despite the low AE and symptom exacerbation rates identified, a timeframe for safe commencement was unable to be established due to poor reporting and/or monitoring of exercise-induced symptoms and AEs in the current literature.
摘要：
■在中度至极重度创伤性脑损伤（TBI）后的恢复早期亚急性期（≤3个月），检查心肺适应性（CRF）评估和训练的安全性。
■根据PRISMA指南完成了系统审查。考虑纳入调查15岁以上中度至极重度TBI的成人和青少年的研究。纳入研究的方法学质量根据McMaster关键审查表-定量研究指南进行评估。
■共有380名参与者的11项研究纳入本综述。不良事件（AE）和症状监测报告不充分。只有四项研究报告了不良事件的发生，共报告了8例AE。报告的不良事件中有三个是脑震荡样症状，没有进一步的运动引起的症状恶化。未报告严重的AE。
■没有证据表明CRF评估和培训在中度至极重度TBI后恢复的早期亚急性阶段是不安全的。然而,尽管AE和症状加重率低，由于目前文献中对运动诱发症状和AE的报告和/或监测不力,因此无法确定安全开始的时间框架.
■根据PRISMA指南完成了系统审查。考虑纳入调查15岁以上中度至极重度TBI的成人和青少年的研究。纳入研究的方法学质量根据McMaster关键审查表-定量研究指南进行评估。
■共有380名参与者的11项研究纳入本综述。不良事件（AE）和症状监测报告不充分。只有四项研究报告了不良事件的发生，共报告了8例AE。报告的不良事件中有三个是脑震荡样症状，没有进一步的运动引起的症状恶化。未报告严重的AE。
■没有证据表明CRF评估和培训在中度至极重度TBI后恢复的早期亚急性阶段是不安全的。然而,尽管AE和症状加重率低，由于目前文献中对运动诱发症状和AE的报告和/或监测不力,因此无法确定安全开始的时间框架.
