吗啡在体外作用以直接引发伤害感受器。
关键词: Morphine nociceptor opioid-induced hyperalgesic priming patch-clamp electrophysiology prostaglandin E2 rheobase sensitization
Mesh : Morphine / pharmacology Animals Nociceptors / drug effects metabolism Dinoprostone / metabolism pharmacology Receptors, Opioid, mu / metabolism Analgesics, Opioid / pharmacology Male Rats Ganglia, Spinal / drug effects metabolism Hyperalgesia / chemically induced drug therapy Rats, Sprague-Dawley Dose-Response Relationship, Drug
来 源:
DOI:10.1177/17448069241260348
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