Abstract：
A Ti3C2Tx/MoS2/MWCNT@rGONR nanocomposite was prepared for the first time for building a sensitive electrochemical aptasening platform to simultaneously detect kanamycin (Kana) and chloramphenicol (Cap). Owing to their accordion-like structure, rich surface groups, and high charge mobility, Ti3C2Tx/MoS2/MWCNT@rGONR composites provided a spacious covalent immobilization surface and a better electrochemical aptasensing platform. The aptamers of Kana and Cap used in sensors enhance the selectivity. Furthermore, TiP, an ion exchanger, was used for loading more different metal ions functioning as labels to form a sandwich-type sensor together with Ti3C2Tx/MoS2/MWCNT@rGONR, improving the electrochemical sensitivity and obtaining a highly distinguishable signal readout. Under the optimized conditions, the sensor has good detection limits of 0.135 nmol L-1 and 0.173 nmol L-1 for Kana and Cap, respectively, at the same linearity concentration of 0.5-2500 nmol L-1. Finally, it was successfully applied for detection in milk and fish meat, and the results were compared with the standard method HPLC, indicating its great potential for food safety monitoring.
摘要：
首次制备了Ti3C2Tx/MoS2/MWCNT@rGONR纳米复合材料，用于建立灵敏的电化学吸附平台，以同时检测卡那霉素（Kana）和氯霉素（Cap）。由于它们像手风琴一样的结构，丰富的表面基团，和高电荷迁移率，Ti3C2Tx/MoS2/MWCNT@rGONR复合材料提供了宽敞的共价固定表面和更好的电化学适应平台。传感器中使用的Kana和Cap的适体增强了选择性。此外，提示,离子交换器,用于加载更多不同的金属离子作为标记物，与Ti3C2Tx/MoS2/MWCNT@rGONR一起形成夹心型传感器，提高电化学灵敏度并获得高度可区分的信号读数。在优化条件下,该传感器对假名和Cap的检测限为0.135nmolL-1和0.173nmolL-1，分别,在相同的线性浓度0.5-2500nmolL-1。最后,它成功地应用于牛奶和鱼肉的检测，并将结果与标准方法HPLC进行比较，表明其在食品安全监管方面的巨大潜力。
