Abstract：
Nanoparticle-based drug delivery systems have emerged as promising platforms for enhancing therapeutic efficacy while minimizing off-target effects. Among various strategies employed to optimize these systems, polyethylene glycol (PEG) modification, known as PEGylation-the covalent attachment of PEG to nanoparticles, has gained considerable attention for its ability to impart stealth properties to nanoparticles while also extending circulation time and improving biocompatibility. PEGylation extends to different drug delivery systems, in specific, nanoparticles for targeting cancer cells, where the concentration of drug in the cancer cells is improved by virtue of PEGylation. The primary challenge linked to PEGylation lies in its confirmation. Numerous research findings provide comprehensive insights into selecting PEG for various PEGylation methods. In this review, we have endeavored to consolidate the outcomes concerning the choice of PEG and diverse PEGylation techniques.
摘要：
基于纳米颗粒的药物递送系统已经成为增强治疗功效同时最小化脱靶效应的有前景的平台。在优化这些系统的各种策略中，聚乙二醇(PEG)修饰,称为聚乙二醇化-PEG与纳米颗粒的共价连接，因其赋予纳米粒子隐身特性，同时延长循环时间和改善生物相容性的能力而获得了相当大的关注。聚乙二醇化延伸到不同的药物递送系统，具体而言,用于靶向癌细胞的纳米粒子，其中通过聚乙二醇化提高了癌细胞中的药物浓度。与聚乙二醇化相关的主要挑战在于其确认。许多研究结果为选择各种聚乙二醇化方法的PEG提供了全面的见解。在这次审查中,我们努力巩固有关选择PEG和多种PEG化技术的结果。
