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Abstract：
UNASSIGNED: Metabolic dysfunction-associated fatty liver disease (MAFLD) is closely associated with serum fibroblast growth factor (FGF) 21; however, previous studies have typically focused on the static fasting state, and the relationships between postprandial FGF21 levels, postprandial metabolic status, and MAFLD remain unclear. Therefore, we measured postprandial lipids, inflammatory factors, and FGF21 levels in MAFLD and further analyzed their relationship using an oral fat tolerance test (OFTT).
UNASSIGNED: In total, 103 non-diabetic adult volunteers, including 46 patients with MAFLD, were included in this study. All participants underwent the OFTT. Venous blood samples were collected at 0, 2, 4, and 6 h. Circulating total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive-C reactive protein(hs-CRP) and FGF21 were assessed.
UNASSIGNED: Serum FGF21 significantly increased in the fasting state (P < 0.05) and showed a biphasic change of first decreasing and then increasing in MAFLD during the OFTT. The postprandial levels of TG, TC, LDL-C, FFA, IL-6, TNF-α and hs-CRP were significantly increased in MAFLD (P < 0.05). After adjusting for multiple factors, the FGF21 incremental area under the curve (iAUC) was linearly correlated with the FFA iAUC, TG iAUC, and IL-6 iAUC (P < 0.05) and was an independent factor for MAFLD (P < 0.05, OR=1.403).
UNASSIGNED: Dyslipidemia and excessive inflammation in MAFLD are associated to FGF21 levels in the postprandial period. An abnormal postprandial FGF21 response may be an important mechanism of MAFLD.
UNASSIGNED: In total, 103 non-diabetic adult volunteers, including 46 patients with MAFLD, were included in this study. All participants underwent the OFTT. Venous blood samples were collected at 0, 2, 4, and 6 h. Circulating total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive-C reactive protein(hs-CRP) and FGF21 were assessed.
UNASSIGNED: Serum FGF21 significantly increased in the fasting state (P < 0.05) and showed a biphasic change of first decreasing and then increasing in MAFLD during the OFTT. The postprandial levels of TG, TC, LDL-C, FFA, IL-6, TNF-α and hs-CRP were significantly increased in MAFLD (P < 0.05). After adjusting for multiple factors, the FGF21 incremental area under the curve (iAUC) was linearly correlated with the FFA iAUC, TG iAUC, and IL-6 iAUC (P < 0.05) and was an independent factor for MAFLD (P < 0.05, OR=1.403).
UNASSIGNED: Dyslipidemia and excessive inflammation in MAFLD are associated to FGF21 levels in the postprandial period. An abnormal postprandial FGF21 response may be an important mechanism of MAFLD.
摘要：
■代谢功能障碍相关的脂肪性肝病(MAFLD)与血清成纤维细胞生长因子(FGF)21密切相关；然而，以前的研究通常集中在静态禁食状态，以及餐后FGF21水平之间的关系，餐后代谢状态，MAFLD仍不清楚。因此,我们测量了餐后血脂，炎症因子，和FGF21在MAFLD中的水平，并使用口服脂肪耐量试验（OFTT）进一步分析了它们之间的关系。
■总共，103名非糖尿病成人志愿者，包括46例MAFLD患者，包括在这项研究中。所有参与者都接受了OFTT。在0、2、4和6小时收集静脉血样本。循环总胆固醇（TC），甘油三酯（TG），游离脂肪酸(FFA),高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），白细胞介素-6（IL-6），肿瘤坏死因子-α(TNF-α),评估超敏C反应蛋白（hs-CRP）和FGF21。
■血清FGF21在空腹状态下显着升高（P<0.05），并在OFTT期间表现出MAFLD先降低后升高的双相变化。餐后TG水平，TC,LDL-C,FFA,MAFLD患者血清IL-6、TNF-α、hs-CRP水平明显升高(P<0.05)。在调整了多个因素后，FGF21增量曲线下面积（iAUC）与FFAiAUC呈线性关系，TGiAUC,IL-6iAUC(P<0.05)是MAFLD的独立影响因素(P<0.05,OR=1.403)。
■MAFLD的血脂异常和过度炎症与餐后FGF21水平相关。餐后FGF21反应异常可能是MAFLD的重要机制。
■总共，103名非糖尿病成人志愿者，包括46例MAFLD患者，包括在这项研究中。所有参与者都接受了OFTT。在0、2、4和6小时收集静脉血样本。循环总胆固醇（TC），甘油三酯（TG），游离脂肪酸(FFA),高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），白细胞介素-6（IL-6），肿瘤坏死因子-α(TNF-α),评估超敏C反应蛋白（hs-CRP）和FGF21。
■血清FGF21在空腹状态下显着升高（P<0.05），并在OFTT期间表现出MAFLD先降低后升高的双相变化。餐后TG水平，TC,LDL-C,FFA,MAFLD患者血清IL-6、TNF-α、hs-CRP水平明显升高(P<0.05)。在调整了多个因素后，FGF21增量曲线下面积（iAUC）与FFAiAUC呈线性关系，TGiAUC,IL-6iAUC(P<0.05)是MAFLD的独立影响因素(P<0.05,OR=1.403)。
■MAFLD的血脂异常和过度炎症与餐后FGF21水平相关。餐后FGF21反应异常可能是MAFLD的重要机制。
