UNASSIGNED: In total, 103 non-diabetic adult volunteers, including 46 patients with MAFLD, were included in this study. All participants underwent the OFTT. Venous blood samples were collected at 0, 2, 4, and 6 h. Circulating total cholesterol (TC), triglyceride (TG), free fatty acid (FFA), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), hypersensitive-C reactive protein(hs-CRP) and FGF21 were assessed.
UNASSIGNED: Serum FGF21 significantly increased in the fasting state (P < 0.05) and showed a biphasic change of first decreasing and then increasing in MAFLD during the OFTT. The postprandial levels of TG, TC, LDL-C, FFA, IL-6, TNF-α and hs-CRP were significantly increased in MAFLD (P < 0.05). After adjusting for multiple factors, the FGF21 incremental area under the curve (iAUC) was linearly correlated with the FFA iAUC, TG iAUC, and IL-6 iAUC (P < 0.05) and was an independent factor for MAFLD (P < 0.05, OR=1.403).
UNASSIGNED: Dyslipidemia and excessive inflammation in MAFLD are associated to FGF21 levels in the postprandial period. An abnormal postprandial FGF21 response may be an important mechanism of MAFLD.
■总共,103名非糖尿病成人志愿者,包括46例MAFLD患者,包括在这项研究中。所有参与者都接受了OFTT。在0、2、4和6小时收集静脉血样本。循环总胆固醇(TC),甘油三酯(TG),游离脂肪酸(FFA),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C),白细胞介素-6(IL-6),肿瘤坏死因子-α(TNF-α),评估超敏C反应蛋白(hs-CRP)和FGF21。
■血清FGF21在空腹状态下显着升高(P<0.05),并在OFTT期间表现出MAFLD先降低后升高的双相变化。餐后TG水平,TC,LDL-C,FFA,MAFLD患者血清IL-6、TNF-α、hs-CRP水平明显升高(P<0.05)。在调整了多个因素后,FGF21增量曲线下面积(iAUC)与FFAiAUC呈线性关系,TGiAUC,IL-6iAUC(P<0.05)是MAFLD的独立影响因素(P<0.05,OR=1.403)。
■MAFLD的血脂异常和过度炎症与餐后FGF21水平相关。餐后FGF21反应异常可能是MAFLD的重要机制。