PDF(Pubmed)
Abstract：
Brain diseases are the most devastating problem among the world\'s increasingly aging population, and the number of patients with neurological diseases is expected to increase in the future. Although methods for delivering drugs to the brain have advanced significantly, none of these approaches provide satisfactory results for the treatment of brain diseases. This remains a challenge due to the unique anatomy and physiology of the brain, including tight regulation and limited access of substances across the blood-brain barrier. Nanoparticles are considered an ideal drug delivery system to hard-to-reach organs such as the brain. The development of new drugs and new nanomaterial-based brain treatments has opened various opportunities for scientists to develop brain-specific delivery systems that could improve treatment outcomes for patients with brain disorders such as Alzheimer\'s disease, Parkinson\'s disease, stroke and brain tumors. In this review, we discuss noteworthy literature that examines recent developments in brain-targeted nanomedicines used in the treatment of neurological diseases.
摘要：
在世界日益老龄化的人口中，脑部疾病是最具破坏性的问题，预计未来神经系统疾病患者的数量将会增加。尽管将药物输送到大脑的方法已经取得了显著进步，这些方法都不能为治疗脑疾病提供令人满意的结果。由于大脑独特的解剖学和生理学，这仍然是一个挑战，包括严格的调节和通过血脑屏障的物质的限制。纳米颗粒被认为是一种理想的药物递送系统，用于难以触及的器官，如大脑。新药和新的基于纳米材料的脑部治疗方法的开发为科学家开发大脑特异性递送系统提供了各种机会，这些系统可以改善患有脑部疾病（如阿尔茨海默病）的患者的治疗结果。帕金森病,中风和脑瘤.在这次审查中,我们讨论了值得注意的文献，这些文献研究了用于治疗神经系统疾病的脑靶向纳米药物的最新进展。
