PDF(Pubmed)
Abstract：
UNASSIGNED: Arsenic, a widely recognized and highly toxic carcinogen, is regarded as one of the most hazardous metalloids globally. However, the precise assessment of acute and chronic human exposure to arsenic and its contributing factors remains unclear in Ethiopia.
UNASSIGNED: The primary goal of this study was to assess the levels of acute and chronic arsenic exposure, as well as the contributing factors, using urine and nail biomarkers.
UNASSIGNED: A community-based analytical cross-sectional study design was employed for this study. Agilent 7900 series inductively coupled plasma mass spectrometry was used to measure the concentrations of arsenic in urine and nail samples. We performed a multiple linear regression analysis to assess the relationships between multiple predictors and outcome variables.
UNASSIGNED: The concentration of arsenic in the urine samples ranged from undetectable (<0.01) to 126.13, with a mean and median concentration of 16.02 and 13.5 μg/L, respectively. However, the mean and median concentration of arsenic in the nails was 1.01, ranging from undetectable (<0.01 μg/g) to 2.54 μg/g. Furthermore, Pearson\'s correlation coefficient analysis showed a significant positive correlation between arsenic concentrations in urine and nail samples (r = 0.432, P < .001). Also, a positive correlation was observed between urinary (r = 0.21, P = .007) and nail (r = 0.14, P = .044) arsenic concentrations and the arsenic concentration in groundwater. Groundwater sources and smoking cigarettes were significantly associated with acute arsenic exposure. In contrast, groundwater sources, cigarette smoking, and the frequency of showers were significantly associated with chronic arsenic exposure.
UNASSIGNED: The study\'s findings unveiled the widespread occurrence of both acute and chronic arsenic exposure in the study area. Consequently, it is crucial to prioritize the residents in the study area and take further measures to prevent both acute and chronic arsenic exposure.
UNASSIGNED: The primary goal of this study was to assess the levels of acute and chronic arsenic exposure, as well as the contributing factors, using urine and nail biomarkers.
UNASSIGNED: A community-based analytical cross-sectional study design was employed for this study. Agilent 7900 series inductively coupled plasma mass spectrometry was used to measure the concentrations of arsenic in urine and nail samples. We performed a multiple linear regression analysis to assess the relationships between multiple predictors and outcome variables.
UNASSIGNED: The concentration of arsenic in the urine samples ranged from undetectable (<0.01) to 126.13, with a mean and median concentration of 16.02 and 13.5 μg/L, respectively. However, the mean and median concentration of arsenic in the nails was 1.01, ranging from undetectable (<0.01 μg/g) to 2.54 μg/g. Furthermore, Pearson\'s correlation coefficient analysis showed a significant positive correlation between arsenic concentrations in urine and nail samples (r = 0.432, P < .001). Also, a positive correlation was observed between urinary (r = 0.21, P = .007) and nail (r = 0.14, P = .044) arsenic concentrations and the arsenic concentration in groundwater. Groundwater sources and smoking cigarettes were significantly associated with acute arsenic exposure. In contrast, groundwater sources, cigarette smoking, and the frequency of showers were significantly associated with chronic arsenic exposure.
UNASSIGNED: The study\'s findings unveiled the widespread occurrence of both acute and chronic arsenic exposure in the study area. Consequently, it is crucial to prioritize the residents in the study area and take further measures to prevent both acute and chronic arsenic exposure.
摘要：
■砷，一种公认的剧毒致癌物,被认为是全球最危险的准金属之一。然而,埃塞俄比亚对急性和慢性人类砷暴露及其影响因素的精确评估尚不清楚.
■这项研究的主要目标是评估急性和慢性砷暴露水平，以及促成因素，使用尿液和指甲生物标志物。
■本研究采用了基于社区的分析横断面研究设计。Agilent7900系列电感耦合等离子体质谱法用于测量尿液和指甲样品中的砷浓度。我们进行了多元线性回归分析，以评估多个预测因子和结果变量之间的关系。
■尿液样本中砷的浓度范围从检测不到（<0.01）到126.13，平均和中值浓度为16.02和13.5μg/L，分别。然而,指甲中砷的平均和中位数浓度为1.01，范围从检测不到（<0.01μg/g）到2.54μg/g。此外，Pearson相关系数分析显示，尿液中砷浓度与指甲样本呈显著正相关（r=0.432，P<.001）。此外，尿（r=0.21，P=.007）和指甲（r=0.14，P=.044）砷浓度与地下水中砷浓度呈正相关。地下水源和吸烟与急性砷暴露显着相关。相比之下,地下水源,吸烟,淋浴频率与慢性砷暴露显著相关。
■这项研究的发现揭示了研究区域内急性和慢性砷暴露的广泛发生。因此,至关重要的是优先考虑研究区域的居民，并采取进一步措施防止急性和慢性砷暴露。
■这项研究的主要目标是评估急性和慢性砷暴露水平，以及促成因素，使用尿液和指甲生物标志物。
■本研究采用了基于社区的分析横断面研究设计。Agilent7900系列电感耦合等离子体质谱法用于测量尿液和指甲样品中的砷浓度。我们进行了多元线性回归分析，以评估多个预测因子和结果变量之间的关系。
■尿液样本中砷的浓度范围从检测不到（<0.01）到126.13，平均和中值浓度为16.02和13.5μg/L，分别。然而,指甲中砷的平均和中位数浓度为1.01，范围从检测不到（<0.01μg/g）到2.54μg/g。此外，Pearson相关系数分析显示，尿液中砷浓度与指甲样本呈显著正相关（r=0.432，P<.001）。此外，尿（r=0.21，P=.007）和指甲（r=0.14，P=.044）砷浓度与地下水中砷浓度呈正相关。地下水源和吸烟与急性砷暴露显着相关。相比之下,地下水源,吸烟,淋浴频率与慢性砷暴露显著相关。
■这项研究的发现揭示了研究区域内急性和慢性砷暴露的广泛发生。因此,至关重要的是优先考虑研究区域的居民，并采取进一步措施防止急性和慢性砷暴露。
