PDF(Pubmed)
Abstract：
Aim: Purified anthocyanins lack a detailed safety profile, prompting the need for comprehensive oral toxicity research. Materials & methods: Sprague-Dawley rats aged 8 weeks received 300 mg/kg cyanidin orally for 14 days in acute toxicity (OECD 423). In the subacute study (OECD 407), adult SD rats were administered 7.5, 15 and 30 mg/kg/day cyanidin orally for 28 days. Results: Acute toxicity indicated an LD50 exceeding 300 mg/kg/day without adverse effects. Subacute toxicity at 7.5-30 mg/kg/day showed well-tolerated responses in both genders. No significant alterations in organ weights, hematological parameters, liver/kidney functions or adverse histopathological findings were observed. Conclusion: Oral cyanidin administration demonstrated high safety and tolerance in rats, establishing a NOAEL at 30 mg/kg/day, affirming cyanidin\'s safety for oral use.
Anthocyanins, natural pigments found in fruits and vegetables, lack a detailed safety profile. This study investigated the oral toxicity of cyanidin, a common anthocyanin. Acute toxicity testing in rats showed no adverse effects at doses up to 300 mg/kg. In the subacute study, doses of 7.5–30 mg/kg/day over 28 days were well tolerated, with no significant negative effects on organ function or histopathology. The findings suggest that cyanidin is safe for oral use in rats, with a No Observed Adverse Effect Level (NOAEL) established at 30 mg/kg/day.
Rat studies reveal cyanidin, a common anthocyanin, shows high oral safety at doses up to 300 mg/kg/day, paving the way for safer dietary supplement use. #Toxicology #SafetyResearch.
Anthocyanins, natural pigments found in fruits and vegetables, lack a detailed safety profile. This study investigated the oral toxicity of cyanidin, a common anthocyanin. Acute toxicity testing in rats showed no adverse effects at doses up to 300 mg/kg. In the subacute study, doses of 7.5–30 mg/kg/day over 28 days were well tolerated, with no significant negative effects on organ function or histopathology. The findings suggest that cyanidin is safe for oral use in rats, with a No Observed Adverse Effect Level (NOAEL) established at 30 mg/kg/day.
Rat studies reveal cyanidin, a common anthocyanin, shows high oral safety at doses up to 300 mg/kg/day, paving the way for safer dietary supplement use. #Toxicology #SafetyResearch.
摘要：
目的：纯化的花青素缺乏详细的安全性，提示需要进行全面的口服毒性研究。材料和方法:8周龄的Sprague-Dawley大鼠在急性毒性中口服300mg/kg矢车菊素14天(OECD423)。在亚急性研究(OECD407)中，成年SD大鼠分别口服7.5、15和30mg/kg/天的花青素，持续28天。结果：急性毒性表明LD50超过300mg/kg/天，无不良反应。7.5-30mg/kg/天的亚急性毒性在两种性别中均显示出良好的耐受性反应。器官重量没有显著变化，血液学参数,观察到肝/肾功能或不良组织病理学结果。结论:大鼠口服矢车菊苷具有较高的安全性和耐受性,建立30毫克/千克/天的NOAEL，肯定花青素口服使用的安全性。
花青素,水果和蔬菜中的天然色素，缺乏详细的安全档案。这项研究调查了花青素的口服毒性，一种常见的花青素。在大鼠中的急性毒性试验显示,在高达300mg/kg的剂量下没有副作用。在亚急性研究中,在28天内7.5-30mg/kg/天的剂量耐受性良好，对器官功能或组织病理学无明显负面影响。研究结果表明，花青素在大鼠中口服使用是安全的，没有观察到的不良反应水平(NOAEL)建立在30mg/kg/天。
大鼠研究揭示了花青素,一种常见的花青素,在剂量高达300mg/kg/天的情况下显示出高口服安全性，为更安全的膳食补充剂使用铺平了道路。#毒理学#SafetyResearch。
花青素,水果和蔬菜中的天然色素，缺乏详细的安全档案。这项研究调查了花青素的口服毒性，一种常见的花青素。在大鼠中的急性毒性试验显示,在高达300mg/kg的剂量下没有副作用。在亚急性研究中,在28天内7.5-30mg/kg/天的剂量耐受性良好，对器官功能或组织病理学无明显负面影响。研究结果表明，花青素在大鼠中口服使用是安全的，没有观察到的不良反应水平(NOAEL)建立在30mg/kg/天。
大鼠研究揭示了花青素,一种常见的花青素,在剂量高达300mg/kg/天的情况下显示出高口服安全性，为更安全的膳食补充剂使用铺平了道路。#毒理学#SafetyResearch。
