PDF(Pubmed)
Abstract：
Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca2+ flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-gated potassium channels (KV), the largest family of K+ channels. Due to the ROS high levels in the aging brain, K+ channels might be affected by oxidative agents and be key in aging and neurodegeneration processes. This review provides new insight about channelopathies in the most studied neurodegenerative disorders, such as Alzheimer Disease, Parkinson\'s Disease, Huntington Disease or Spinocerebellar Ataxia. The main affected KV channels in these neurodegenerative diseases are the KV1, KV2.1, KV3, KV4 and KV7. Moreover, in order to prevent or repair the development of these neurodegenerative diseases, previous KV channel modulators have been proposed as therapeutic targets.
摘要：
电压门控离子通道对于维持膜电位至关重要，稳态，电信号的产生和控制通过膜的Ca2+流动。在所有离子通道中，神经元兴奋性的关键调节因子是电压门控钾通道(KV),最大的K+频道家族。由于衰老大脑中的ROS水平很高，K+通道可能受到氧化剂的影响,并且是衰老和神经变性过程中的关键。这篇综述为研究最多的神经退行性疾病中的通道病提供了新的见解，比如阿尔茨海默病，帕金森病,亨廷顿病或脊髓小脑共济失调。这些神经退行性疾病中主要受影响的KV通道是KV1、KV2.1、KV3、KV4和KV7。此外，为了预防或修复这些神经退行性疾病的发展，先前的KV通道调节剂已被提出作为治疗靶标。
