PDF(Pubmed)
Abstract：
UNASSIGNED: Abnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migraine.
UNASSIGNED: To date, no studies have investigated both afterimage duration and CNV parameters in the same subjects. The aim of this study was to investigate the relationship between the early component of CNV (iCNV) and the duration of the afterimage in migraine patients.
UNASSIGNED: Sixty seven migraine patients from the headache center of the University of Rostock Medical Center were examined for iCNV amplitude, iCNV habituation and afterimage duration. The subjects also completed questionnaires developed for this study and the MIDAS (Migraine Disability Assessment) questionnaire.
UNASSIGNED: Associations were found between iCNV amplitude and afterimage duration and between habituation capacity and afterimage duration. A deficit in habituation capacity correlated with a significantly prolonged afterimage duration. Increased iCNV amplitude and prolonged afterimage duration were also significantly correlated.
UNASSIGNED: Conclusions about the pathophysiology of migraine can be drawn from the results of this study. The results support the hypothesis of cortical hyperexcitability as a consequence of a low pre-activation level, which may be a possible contributory cause of migraine. Furthermore, they allow assessment of whether the afterimage examination, which is easier and quicker to perform than the CNV examination, can be used as a diagnostic tool or as a parameter to monitor the course of therapy in people with migraine.
UNASSIGNED: To date, no studies have investigated both afterimage duration and CNV parameters in the same subjects. The aim of this study was to investigate the relationship between the early component of CNV (iCNV) and the duration of the afterimage in migraine patients.
UNASSIGNED: Sixty seven migraine patients from the headache center of the University of Rostock Medical Center were examined for iCNV amplitude, iCNV habituation and afterimage duration. The subjects also completed questionnaires developed for this study and the MIDAS (Migraine Disability Assessment) questionnaire.
UNASSIGNED: Associations were found between iCNV amplitude and afterimage duration and between habituation capacity and afterimage duration. A deficit in habituation capacity correlated with a significantly prolonged afterimage duration. Increased iCNV amplitude and prolonged afterimage duration were also significantly correlated.
UNASSIGNED: Conclusions about the pathophysiology of migraine can be drawn from the results of this study. The results support the hypothesis of cortical hyperexcitability as a consequence of a low pre-activation level, which may be a possible contributory cause of migraine. Furthermore, they allow assessment of whether the afterimage examination, which is easier and quicker to perform than the CNV examination, can be used as a diagnostic tool or as a parameter to monitor the course of therapy in people with migraine.
摘要：
■已知在偏头痛患者中会发生皮层电参数异常和视觉刺激后残影的持续存在。对偏头痛患者的或有阴性变化（CNV）和余像持久性的研究结果表明，这两种现象之间存在联系，并且与偏头痛的发病机制有关。
■到目前为止，没有研究调查了同一受试者的残像持续时间和CNV参数。这项研究的目的是调查偏头痛患者的CNV（iCNV）的早期成分与残像持续时间之间的关系。
■来自罗斯托克大学医学中心头痛中心的67名偏头痛患者接受了iCNV振幅检查，iCNV习惯化和残像持续时间。受试者还完成了为本研究开发的问卷和MIDAS（偏头痛残疾评估）问卷。
■在iCNV振幅和余像持续时间之间以及在习惯能力和余像持续时间之间发现了关联。习惯能力不足与残像持续时间明显延长有关。iCNV振幅的增加和余像持续时间的延长也显着相关。
■从这项研究的结果可以得出关于偏头痛的病理生理学的结论。结果支持皮质过度兴奋的假设，作为一个低的预激活水平的结果，这可能是偏头痛的一个可能的原因。此外，它们允许评估残像检查，这比CNV检查更容易和更快地执行，可以用作诊断工具或参数来监测偏头痛患者的治疗过程。
■到目前为止，没有研究调查了同一受试者的残像持续时间和CNV参数。这项研究的目的是调查偏头痛患者的CNV（iCNV）的早期成分与残像持续时间之间的关系。
■来自罗斯托克大学医学中心头痛中心的67名偏头痛患者接受了iCNV振幅检查，iCNV习惯化和残像持续时间。受试者还完成了为本研究开发的问卷和MIDAS（偏头痛残疾评估）问卷。
■在iCNV振幅和余像持续时间之间以及在习惯能力和余像持续时间之间发现了关联。习惯能力不足与残像持续时间明显延长有关。iCNV振幅的增加和余像持续时间的延长也显着相关。
■从这项研究的结果可以得出关于偏头痛的病理生理学的结论。结果支持皮质过度兴奋的假设，作为一个低的预激活水平的结果，这可能是偏头痛的一个可能的原因。此外，它们允许评估残像检查，这比CNV检查更容易和更快地执行，可以用作诊断工具或参数来监测偏头痛患者的治疗过程。
