PDF(Pubmed)
Abstract：
UNASSIGNED: Evidence has suggested that microRNAs (miRNAs) may play an important role in the pathogenesis of psychiatric disorders (PDs), but the results remain inconclusive. We aimed to identify specific differentially expressed miRNAs and their overlapping miRNA expression profiles in schizophrenia (SZ), major depression disorder (MDD), and bipolar disorder (BD), the three major PDs.
UNASSIGNED: The literatures up to September 30, 2023 related to peripheral blood miRNAs and PDs were searched and screened from multiple databases. The differences in miRNA levels between groups were illustrated by the standardized mean difference (SMD) and 95% confidence interval (95% CI).
UNASSIGNED: In total, 30 peripheral blood miRNAs were included in the meta-analysis, including 16 for SZ, 12 for MDD, and 2 for BD, each was reported in more than 3 independent studies. Compared with the control group, miR-181b-5p, miR-34a-5p, miR-195-5p, miR-30e-5p, miR-7-5p, miR-132-3p, miR-212-3p, miR-206, miR-92a-3p and miR-137-3p were upregulated in SZ, while miR-134-5p, miR-107 and miR-99b-5p were downregulated. In MDD, miR-124-3p, miR-132-3p, miR-139-5p, miR-182-5p, miR-221-3p, miR-34a-5p and miR-93-5p were upregulated, while miR-144-5p and miR-135a-5p were downregulated. However, we failed to identify statistically differentially expressed miRNAs in BD. Interestingly, miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD.
UNASSIGNED: Our study identified 13 differentially expressed miRNAs in SZ and 9 in MDD, among which miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD by systematically analyzing qualified studies. These miRNAs may be used as potential biomarkers for the diagnosis of SZ and MDD in the future.
UNASSIGNED: http://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486982.
UNASSIGNED: The literatures up to September 30, 2023 related to peripheral blood miRNAs and PDs were searched and screened from multiple databases. The differences in miRNA levels between groups were illustrated by the standardized mean difference (SMD) and 95% confidence interval (95% CI).
UNASSIGNED: In total, 30 peripheral blood miRNAs were included in the meta-analysis, including 16 for SZ, 12 for MDD, and 2 for BD, each was reported in more than 3 independent studies. Compared with the control group, miR-181b-5p, miR-34a-5p, miR-195-5p, miR-30e-5p, miR-7-5p, miR-132-3p, miR-212-3p, miR-206, miR-92a-3p and miR-137-3p were upregulated in SZ, while miR-134-5p, miR-107 and miR-99b-5p were downregulated. In MDD, miR-124-3p, miR-132-3p, miR-139-5p, miR-182-5p, miR-221-3p, miR-34a-5p and miR-93-5p were upregulated, while miR-144-5p and miR-135a-5p were downregulated. However, we failed to identify statistically differentially expressed miRNAs in BD. Interestingly, miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD.
UNASSIGNED: Our study identified 13 differentially expressed miRNAs in SZ and 9 in MDD, among which miR-132-3p and miR-34a-5p were upregulated in both SZ and MDD by systematically analyzing qualified studies. These miRNAs may be used as potential biomarkers for the diagnosis of SZ and MDD in the future.
UNASSIGNED: http://www.crd.york.ac.uk/PROSPERO, identifier CRD42023486982.
摘要：
■证据表明，microRNAs（miRNAs）可能在精神疾病（PDs）的发病机制中起重要作用，但结果尚无定论。我们旨在鉴定精神分裂症（SZ）中特定差异表达的miRNA及其重叠的miRNA表达谱，重度抑郁症（MDD），和双相情感障碍（BD），三大PD。
■从多个数据库中搜索并筛选截至2023年9月30日与外周血miRNA和PD相关的文献。通过标准化平均差(SMD)和95%置信区间(95%CI)说明了组间miRNA水平的差异。
■总共，30个外周血miRNAs纳入meta分析,包括深圳的16个，12对于MDD，2为BD，在超过3项独立研究中报告了每项研究.与对照组相比,miR-181b-5p,miR-34a-5p,miR-195-5p,miR-30e-5p,miR-7-5p,miR-132-3p,miR-212-3p,miR-206，miR-92a-3p和miR-137-3p在SZ中上调，而miR-134-5p,miR-107和miR-99b-5p下调。在MDD中，miR-124-3p,miR-132-3p,miR-139-5p,miR-182-5p,miR-221-3p,miR-34a-5p和miR-93-5p上调,而miR-144-5p和miR-135a-5p下调。然而,我们未能鉴定BD中统计学差异表达的miRNA。有趣的是,miR-132-3p和miR-34a-5p在SZ和MDD中均上调。
■我们的研究确定了SZ中的13种差异表达的miRNA和MDD中的9种差异表达的miRNA，通过系统分析合格研究,其中miR-132-3p和miR-34a-5p在SZ和MDD中均上调.这些miRNAs有可能作为诊断SZ和MDD的潜在生物标志物。
■http://www.crd.约克。AC.英国/PROSPERO,标识符CRD42023486982。
■从多个数据库中搜索并筛选截至2023年9月30日与外周血miRNA和PD相关的文献。通过标准化平均差(SMD)和95%置信区间(95%CI)说明了组间miRNA水平的差异。
■总共，30个外周血miRNAs纳入meta分析,包括深圳的16个，12对于MDD，2为BD，在超过3项独立研究中报告了每项研究.与对照组相比,miR-181b-5p,miR-34a-5p,miR-195-5p,miR-30e-5p,miR-7-5p,miR-132-3p,miR-212-3p,miR-206，miR-92a-3p和miR-137-3p在SZ中上调，而miR-134-5p,miR-107和miR-99b-5p下调。在MDD中，miR-124-3p,miR-132-3p,miR-139-5p,miR-182-5p,miR-221-3p,miR-34a-5p和miR-93-5p上调,而miR-144-5p和miR-135a-5p下调。然而,我们未能鉴定BD中统计学差异表达的miRNA。有趣的是,miR-132-3p和miR-34a-5p在SZ和MDD中均上调。
■我们的研究确定了SZ中的13种差异表达的miRNA和MDD中的9种差异表达的miRNA，通过系统分析合格研究,其中miR-132-3p和miR-34a-5p在SZ和MDD中均上调.这些miRNAs有可能作为诊断SZ和MDD的潜在生物标志物。
■http://www.crd.约克。AC.英国/PROSPERO,标识符CRD42023486982。
