PDF(Pubmed)
Abstract：
Monoclonal gammopathy of undetermined significance (MGUS) is a pre-neoplastic condition involving plasma cells or lymphoplasmacytic proliferation-clinical presentations ranging from asymptomatic to symptoms of systematic organ involvement. It is commonly associated with light chain amyloidosis and usually strengthens during diagnosis. It is usually associated with thrombocytopenia in addition to anemia. This case report focuses on a 63-year-old Hispanic female who initially presented without any symptoms but with severe thrombocytosis. The finding of renal amyloidosis boosts the final diagnosis of MGUS. Rarely a patient is initially presented with severe thrombocytosis despite thrombocytopenia, which is commonly associated with plasma cell disorders. The case emphasizes the need for considering plasma cell disorders in patients with abnormal hematologic manifestations. It highlights the importance of timely identification and intervention to prevent irreversible organ damage by providing a detailed analysis of the clinical presentation and diagnostic evaluation.
摘要：
意义不明的单克隆丙种球蛋白病（MGUS）是一种肿瘤前疾病，涉及浆细胞或淋巴浆细胞增殖-临床表现，从无症状到系统性器官受累的症状。它通常与轻链淀粉样变性有关，通常在诊断过程中增强。除贫血外，它通常与血小板减少症有关。该病例报告的重点是一名63岁的西班牙裔女性，该女性最初没有任何症状，但患有严重的血小板增多症。肾淀粉样变性的发现促进了MGUS的最终诊断。尽管血小板减少，但很少有患者最初出现严重的血小板增多症。这通常与浆细胞疾病有关。该病例强调需要考虑血液学表现异常的患者的浆细胞疾病。通过提供对临床表现和诊断评估的详细分析，强调了及时识别和干预以防止不可逆器官损害的重要性。
