PDF(Pubmed)
Abstract：
UNASSIGNED: Since the first report, primary mediastinal seminoma has a low incidence in the population, and it mainly affects young and middle-aged men, is clinically rare, and accounts for a very small proportion of mediastinal tumors. In this study, we describe the first case of primary mediastinal seminoma with azoospermia and hypothesize that the coexistence of the two disorders may not be a coincidence.
UNASSIGNED: A 16-year-old man presented with chest tightness and chest pain, a mediastinal mass on chest CT, and abnormal 18F-fluoro-deoxyglucose uptake on a PET-CT scan. By biopsy of the mass, the pathological diagnosis was a primary mediastinal seminoma. Because chemotherapy is included in the treatment of the tumor, the patient underwent sperm freezing before treatment, considering that chemotherapy can affect fertility, but the patient was diagnosed with azoospermia. Finally, the patient underwent tumor resection and postoperative chemotherapy. No tumor recurrence was observed at the current follow-up.
UNASSIGNED: Primary mediastinal seminoma is mainly confirmed by histopathological examination, and surgery and chemoradiotherapy are the current treatments. In patients with mediastinal seminoma or azoospermia, doctors should be aware that the two disorders may coexist, especially in men who have fertility requirements or long-term infertility, and that examination of the mediastinum and semen may lead to unexpected findings in the diagnosis and treatment. For mediastinal germ cell tumors, genetic testing is of great value in the treatment of tumors and the prediction of associated diseases. Future studies exploring the potential correlation between mediastinal seminoma and azoospermia will be prospective.
UNASSIGNED: A 16-year-old man presented with chest tightness and chest pain, a mediastinal mass on chest CT, and abnormal 18F-fluoro-deoxyglucose uptake on a PET-CT scan. By biopsy of the mass, the pathological diagnosis was a primary mediastinal seminoma. Because chemotherapy is included in the treatment of the tumor, the patient underwent sperm freezing before treatment, considering that chemotherapy can affect fertility, but the patient was diagnosed with azoospermia. Finally, the patient underwent tumor resection and postoperative chemotherapy. No tumor recurrence was observed at the current follow-up.
UNASSIGNED: Primary mediastinal seminoma is mainly confirmed by histopathological examination, and surgery and chemoradiotherapy are the current treatments. In patients with mediastinal seminoma or azoospermia, doctors should be aware that the two disorders may coexist, especially in men who have fertility requirements or long-term infertility, and that examination of the mediastinum and semen may lead to unexpected findings in the diagnosis and treatment. For mediastinal germ cell tumors, genetic testing is of great value in the treatment of tumors and the prediction of associated diseases. Future studies exploring the potential correlation between mediastinal seminoma and azoospermia will be prospective.
摘要：
■自第一份报告以来，原发性纵隔精原细胞瘤在人群中发病率较低，它主要影响中青年男性，在临床上很罕见，占纵隔肿瘤的比例很小。在这项研究中,我们描述了第一例原发性纵隔精原细胞瘤伴无精子症，并假设这两种疾病的共存可能不是巧合。
■一名16岁男子出现胸闷和胸痛,胸部CT显示纵隔肿块,PET-CT扫描显示18F-氟代脱氧葡萄糖摄取异常。通过肿块的活检，病理诊断为原发性纵隔精原细胞瘤。因为化疗包括在肿瘤的治疗中，患者在治疗前接受了精子冷冻，考虑到化疗会影响生育能力，但病人被诊断为无精子症.最后,患者接受了肿瘤切除和术后化疗。目前随访未见肿瘤复发。
■原发性纵隔精原细胞瘤主要通过组织病理学检查证实，手术和放化疗是目前的治疗方法。纵隔精原细胞瘤或无精子症患者，医生应该意识到这两种疾病可能共存，尤其是有生育要求或长期不孕症的男性，纵隔和精液检查可能会导致诊断和治疗中意想不到的发现。纵隔生殖细胞肿瘤，基因检测在肿瘤的治疗和相关疾病的预测中具有重要价值。探索纵隔精原细胞瘤和无精子症之间潜在相关性的未来研究将是前瞻性的。
■一名16岁男子出现胸闷和胸痛,胸部CT显示纵隔肿块,PET-CT扫描显示18F-氟代脱氧葡萄糖摄取异常。通过肿块的活检，病理诊断为原发性纵隔精原细胞瘤。因为化疗包括在肿瘤的治疗中，患者在治疗前接受了精子冷冻，考虑到化疗会影响生育能力，但病人被诊断为无精子症.最后,患者接受了肿瘤切除和术后化疗。目前随访未见肿瘤复发。
■原发性纵隔精原细胞瘤主要通过组织病理学检查证实，手术和放化疗是目前的治疗方法。纵隔精原细胞瘤或无精子症患者，医生应该意识到这两种疾病可能共存，尤其是有生育要求或长期不孕症的男性，纵隔和精液检查可能会导致诊断和治疗中意想不到的发现。纵隔生殖细胞肿瘤，基因检测在肿瘤的治疗和相关疾病的预测中具有重要价值。探索纵隔精原细胞瘤和无精子症之间潜在相关性的未来研究将是前瞻性的。
