PDF(Pubmed)
Abstract：
Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or functional magnetic resonance imaging to resolve the structure pattern and functional activity during subtraction operation. However, a high resolution of the spatial-temporal understanding of the neural mechanisms involved in mental subtraction is unavailable. Thus, this study obtained intracranial stereoelectroencephalography recordings from 20 patients with pharmacologically resistant epilepsy. Specifically, two sample-delayed mismatch paradigms of numeric comparison and subtracting results comparison were used to help reveal the time frame of mental subtraction. The brain sub-regions were chronologically screened using the stereoelectroencephalography recording for mental subtraction. The results indicated that the anterior cortex, containing the frontal, insular, and parahippocampous, worked for preparing for mental subtraction; moreover, the posterior cortex, such as parietal, occipital, limbic, and temporal regions, cooperated during subtraction. Especially, the gamma band activities in core regions within the parietal-cingulate-temporal cortices mediated the critical mental subtraction. Overall, this research is the first to describe the spatiotemporal activities underlying mental subtraction in the human brain. It provides a comprehensive insight into the cognitive control activity underlying mental arithmetic.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s11571-023-09937-z.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s11571-023-09937-z.
摘要：
心理减法，涉及数值处理和运算，需要几个大脑区域之间复杂的相互作用。各种研究都利用头皮脑电图，皮质电图,或功能磁共振成像来解析减影操作过程中的结构模式和功能活动。然而,对心理减影中涉及的神经机制的时空理解的高分辨率是不可用的。因此，这项研究获得了20例药物难治性癫痫患者的颅内立体脑电图记录。具体来说,使用了数字比较和减法结果比较的两种样本延迟失配范式来帮助揭示心理减法的时间框架。使用用于心理减影的立体脑电图记录按时间顺序筛选大脑子区域。结果表明，前皮质，包含额叶，岛屿,和海马旁，为心理减法做准备；此外，后皮层，如顶骨，枕骨,边缘,和时间区域，在减法中合作。尤其是,顶叶-扣带回-颞叶皮质核心区域的伽马带活动介导了关键的心理减影。总的来说,这项研究首次描述了人类大脑中心理减法的时空活动。它提供了对心理算术基础的认知控制活动的全面了解。
■在线版本包含补充材料，可在10.1007/s11571-023-09937-z获得。
■在线版本包含补充材料，可在10.1007/s11571-023-09937-z获得。
