PDF(Pubmed)
Abstract：
Increasingly Charcot neuroarthropathy (CN) is being recognized in patients with Charcot-Marie-Tooth (CMT) disease. In this report, we describe a case of CN in a CMT patient, adding to the very scarce literature describing this association. We additionally report his unique evaluation with fluorodeoxyglucose (FDG) and sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) scanning, the study of which is limited in CN despite its promising role. A 54-year-old known case of CMT, presented with left foot pain, and swelling for 4 months. Weakness and sensory deficits as a result of CMT were evident in both lower and upper limbs. His x-ray was suggestive of CN. Both FDG and NaF PET/CT scanning demonstrated increased tracer uptake in the first tarsometatarsal joint (TMTJ), in keeping with CN. Recognition of the association of CMT with CN is of vital importance as early diagnosis relies on high clinical suspicion. Characterizing risk factors of CN in CMT patients is still under study. Moreover, there is lack of data evaluating the role of PET/CT in CN and specifically in the context of CMT.
摘要：
Charcot神经关节病（CN）在Charcot-Marie-Tooth（CMT）患者中得到了越来越多的认可。在这份报告中,我们描述了一个CMT患者的CN病例，增加了描述这种关联的非常稀缺的文献。我们还通过氟脱氧葡萄糖（FDG）和氟化钠（NaF）正电子发射断层扫描/计算机断层扫描（PET/CT）扫描报告了他的独特评估，尽管其作用很有希望，但其研究在CN中受到限制。一个54岁的已知CMT病例，出现左脚疼痛，和肿胀4个月。由于CMT导致的虚弱和感觉缺陷在下肢和上肢都很明显。他的X光提示CN。FDG和NaFPET/CT扫描均显示在第一滑掌关节（TMTJ）中示踪剂摄取增加，与CN保持一致。认识到CMT与CN的关联至关重要，因为早期诊断依赖于高度的临床怀疑。CMT患者中CN的危险因素特征仍在研究中。此外，缺乏评估PET/CT在CN中，特别是在CMT中的作用的数据。
