PDF(Pubmed)
Abstract：
OBJECTIVE: Total hip arthroplasty (THA) is a highly successful and effective surgery for improving hip functions and relieving pain. However, the lower extremities are prone to deep vein thrombosis (DVT) and swelling after surgery, thereby delaying recovery. In this study, we investigated the preventive effects of fondaparinux sodium (FS) and low-molecular-weight heparin (LMWH) on DVT of the lower extremity after THA.
METHODS: Firstly, 60 patients who underwent THA at the First Affiliated Hospital of Wannan Medical College from March 2020 to December 2020 were included. Next, the patients were randomly divided into an LMWH group (n = 30) and an FS group (n = 30). Then, the indexes related to DVT were compared between both groups.
RESULTS: Specifically, the differences in baseline data, such as age, gender and body mass index (BMI), between the two groups were not statistically significant. The postoperative weight bearing time of patients in the FS group was much shorter than that in the LMWH group.
CONCLUSIONS: Subcutaneous injection of FS not only exhibits superior effects to LMWH in preventing DVT after THA but also has a correlation with reducing the risk of thrombosis and improving patient symptoms.
METHODS: Firstly, 60 patients who underwent THA at the First Affiliated Hospital of Wannan Medical College from March 2020 to December 2020 were included. Next, the patients were randomly divided into an LMWH group (n = 30) and an FS group (n = 30). Then, the indexes related to DVT were compared between both groups.
RESULTS: Specifically, the differences in baseline data, such as age, gender and body mass index (BMI), between the two groups were not statistically significant. The postoperative weight bearing time of patients in the FS group was much shorter than that in the LMWH group.
CONCLUSIONS: Subcutaneous injection of FS not only exhibits superior effects to LMWH in preventing DVT after THA but also has a correlation with reducing the risk of thrombosis and improving patient symptoms.
摘要：
目的：全髋关节置换术（THA）是一种非常成功和有效的改善髋关节功能和减轻疼痛的手术。然而,下肢容易发生深静脉血栓(DVT)和术后肿胀,从而延迟恢复。在这项研究中,我们研究了磺达肝素钠(FS)和低分子肝素(LMWH)对THA后下肢DVT的预防作用.
方法：首先，纳入2020年3月至2020年12月在皖南医学院第一附属医院接受THA的60例患者。接下来,将患者随机分为LMWH组(n=30)和FS组(n=30).然后，比较两组DVT相关指标.
结果：具体来说，基线数据的差异，比如年龄,性别和体重指数（BMI），两组间差异无统计学意义。FS组患者术后负重时间明显短于LMWH组。
结论：皮下注射FS不仅在预防THA后DVT方面优于LMWH，而且与降低血栓形成风险和改善患者症状具有相关性。
方法：首先，纳入2020年3月至2020年12月在皖南医学院第一附属医院接受THA的60例患者。接下来,将患者随机分为LMWH组(n=30)和FS组(n=30).然后，比较两组DVT相关指标.
结果：具体来说，基线数据的差异，比如年龄,性别和体重指数（BMI），两组间差异无统计学意义。FS组患者术后负重时间明显短于LMWH组。
结论：皮下注射FS不仅在预防THA后DVT方面优于LMWH，而且与降低血栓形成风险和改善患者症状具有相关性。
