PDF(Pubmed)
Abstract：
OBJECTIVE: This study aimed to analyze and map scientific literature on Neuroleptic Malignant Syndrome (NMS) and Serotonin Syndrome (SS) from prestigious, internationally indexed journals. The objective was to identify key topics, impactful articles, prominent journals, research output, growth patterns, hotspots, and leading countries in the field, providing valuable insights for scholars, medical students, and international funding agencies.
METHODS: A systematic search strategy was implemented in the PubMed MeSH database using specific keywords for NMS and SS. The search was conducted in the Scopus database, renowned for its extensive coverage of scholarly publications. Inclusion criteria comprised articles published from 1950 to December 31st, 2022, restricted to journal research and review articles written in English. Data were analyzed using Microsoft Excel for descriptive analysis, and VOSviewer was employed for bibliometric mapping.
RESULTS: The search yielded 1150 articles on NMS and 587 on SS, with the majority being case reports. Growth patterns revealed a surge in NMS research between 1981 and 1991, while SS research increased notably between 1993 and 1997. Active countries and journals differed between NMS and SS, with psychiatry journals predominating for NMS and pharmacology/toxicology journals for SS. Authorship analysis indicated higher multi-authored articles for NMS. Top impactful articles focused on review articles and pathogenic mechanisms. Research hotspots included antipsychotics and catatonia for NMS, while SS highlighted drug interactions and specific medications like linezolid and tramadol.
CONCLUSIONS: NMS and SS represent rare but life-threatening conditions, requiring detailed clinical and scientific understanding. Differential diagnosis and management necessitate caution in prescribing medications affecting central serotonin or dopamine systems, with awareness of potential drug interactions. International diagnostic tools and genetic screening tests may aid in safe diagnosis and prevention. Reporting rare cases and utilizing bibliometric analysis enhance knowledge dissemination and research exploration in the field of rare drug-induced medical conditions.
METHODS: A systematic search strategy was implemented in the PubMed MeSH database using specific keywords for NMS and SS. The search was conducted in the Scopus database, renowned for its extensive coverage of scholarly publications. Inclusion criteria comprised articles published from 1950 to December 31st, 2022, restricted to journal research and review articles written in English. Data were analyzed using Microsoft Excel for descriptive analysis, and VOSviewer was employed for bibliometric mapping.
RESULTS: The search yielded 1150 articles on NMS and 587 on SS, with the majority being case reports. Growth patterns revealed a surge in NMS research between 1981 and 1991, while SS research increased notably between 1993 and 1997. Active countries and journals differed between NMS and SS, with psychiatry journals predominating for NMS and pharmacology/toxicology journals for SS. Authorship analysis indicated higher multi-authored articles for NMS. Top impactful articles focused on review articles and pathogenic mechanisms. Research hotspots included antipsychotics and catatonia for NMS, while SS highlighted drug interactions and specific medications like linezolid and tramadol.
CONCLUSIONS: NMS and SS represent rare but life-threatening conditions, requiring detailed clinical and scientific understanding. Differential diagnosis and management necessitate caution in prescribing medications affecting central serotonin or dopamine systems, with awareness of potential drug interactions. International diagnostic tools and genetic screening tests may aid in safe diagnosis and prevention. Reporting rare cases and utilizing bibliometric analysis enhance knowledge dissemination and research exploration in the field of rare drug-induced medical conditions.
摘要：
目的：本研究旨在分析和绘制来自著名的抗精神病药恶性综合征（NMS）和5-羟色胺综合征（SS）的科学文献，国际索引期刊。目的是确定关键主题，有影响力的文章，著名期刊,研究成果，增长模式，热点,以及该领域的领先国家，为学者提供有价值的见解，医学生,和国际资助机构。
方法：在PubMedMeSH数据库中使用NMS和SS的特定关键字实施了系统搜索策略。搜索是在Scopus数据库中进行的，以广泛的学术出版物而闻名。纳入标准包括1950年至12月31日发表的文章，2022年，仅限于以英语撰写的期刊研究和评论文章。使用MicrosoftExcel对数据进行描述性分析，采用VOSviewer进行文献计量制图。
结果：搜索产生了1150篇关于NMS的文章和587篇关于SS的文章，大多数是病例报告。增长模式显示1981年至1991年期间NMS研究激增，而SS研究在1993年至1997年期间显着增加。活跃的国家和期刊在NMS和SS之间有所不同，以NMS为主的精神病学期刊和SS的药理学/毒理学期刊。作者分析显示，NMS的多作者文章较多。有影响力的文章主要集中在综述文章和致病机制上。研究热点包括抗精神病药和NMS的卡顿，而SS强调了药物相互作用和利奈唑胺和曲马多等特定药物。
结论：NMS和SS代表罕见但危及生命的疾病，需要详细的临床和科学的理解。鉴别诊断和管理需要谨慎处方影响中枢5-羟色胺或多巴胺系统的药物，意识到潜在的药物相互作用。国际诊断工具和基因筛查测试可能有助于安全诊断和预防。报告罕见病例并利用文献计量分析增强了罕见药物引起的医疗状况领域的知识传播和研究探索。
方法：在PubMedMeSH数据库中使用NMS和SS的特定关键字实施了系统搜索策略。搜索是在Scopus数据库中进行的，以广泛的学术出版物而闻名。纳入标准包括1950年至12月31日发表的文章，2022年，仅限于以英语撰写的期刊研究和评论文章。使用MicrosoftExcel对数据进行描述性分析，采用VOSviewer进行文献计量制图。
结果：搜索产生了1150篇关于NMS的文章和587篇关于SS的文章，大多数是病例报告。增长模式显示1981年至1991年期间NMS研究激增，而SS研究在1993年至1997年期间显着增加。活跃的国家和期刊在NMS和SS之间有所不同，以NMS为主的精神病学期刊和SS的药理学/毒理学期刊。作者分析显示，NMS的多作者文章较多。有影响力的文章主要集中在综述文章和致病机制上。研究热点包括抗精神病药和NMS的卡顿，而SS强调了药物相互作用和利奈唑胺和曲马多等特定药物。
结论：NMS和SS代表罕见但危及生命的疾病，需要详细的临床和科学的理解。鉴别诊断和管理需要谨慎处方影响中枢5-羟色胺或多巴胺系统的药物，意识到潜在的药物相互作用。国际诊断工具和基因筛查测试可能有助于安全诊断和预防。报告罕见病例并利用文献计量分析增强了罕见药物引起的医疗状况领域的知识传播和研究探索。
