Abstract：
Docetaxel (DTX) is a key drug used in perioperative chemotherapy for breast cancer. Edema is a known adverse effect of DTX, but its effect on health-related QOL (HRQOL) is unclear. In this study, we evaluated the effects of edema caused by administration of DTX on HRQOL in patients with early-stage breast cancer. We prospectively investigated patients diagnosed with early-stage breast cancer (stage I-III) who received 4 cycles of DTX as preoperative or postoperative chemotherapy between September 2021 and December 2022 at Yamanashi Prefectural Central Hospital. The circumference of each extremity was measured at each administration of DTX, and limb edema was evaluated by Common Terminology Criteria for Adverse Events version 5.0. HRQOL was evaluated using SF-12 version 2, which has a range of 0-100 (national standard, 50), and compared between the presence and absence of grade 2 or higher edema and between before and after administration of DTX. Twenty patients met the eligibility criteria and were included in the study. There was no difference in the HRQOL score according to whether grade 2 limb edema was present. The median HRQOL summary scores before and after administration of DTX were 51.1 and 50.8 (p=0.763), respectively, for mental health, 52.6 and 49.4 (p=0.005) for physical health, and 38.9 and 37.5 (p=1.000) for role/social health. We found no direct effect of DTX-induced limb edema on HRQOL in patients with early-stage breast cancer. However, HRQOL summary scores indicated that administration of DTX reduced physical health in these patients.
摘要：
多西他赛（DTX）是乳腺癌围手术期化疗的关键药物。水肿是DTX的已知不良反应，但其对健康相关生活质量（HRQOL）的影响尚不清楚。在这项研究中,我们评估了早期乳腺癌患者服用DTX引起的水肿对HRQOL的影响.我们前瞻性调查了2021年9月至2022年12月在山梨县中心医院接受4周期DTX术前或术后化疗的早期乳腺癌（I-III期）患者。在每次服用DTX时测量每个肢体的周长，和肢体水肿通过5.0版不良事件通用术语标准进行评估。HRQOL使用SF-12版本2进行评估，其范围为0-100（国家标准，50),并比较2级或更高水肿的存在和不存在以及DTX给药前后之间的差异。20名患者符合资格标准并被纳入研究。根据是否存在2级肢体水肿，HRQOL评分没有差异。给予DTX前后的HRQOL总分中位数分别为51.1和50.8（p=0.763），分别,为了心理健康，身体健康52.6和49.4(p=0.005)，角色/社会健康为38.9和37.5（p=1.000）。我们发现DTX引起的肢体水肿对早期乳腺癌患者的HRQOL没有直接影响。然而,HRQOL汇总评分表明,给予DTX降低了这些患者的身体健康。
