Abstract：
Estrogen and related receptors have been shown to have a significant impact on human development, reproduction, metabolism and immune regulation and to play a critical role in tumor development and treatment. Traditionally, the nuclear estrogen receptors (nERs) ERα and ERβ have been thought to be involved in mediating the estrogenic effects. However, our group and others have previously demonstrated that the G protein-coupled estrogen receptor (GPER) is the third independent ER, and estrogen signaling mediated by GPER is known to play an important role in normal physiology and a variety of abnormal diseases. Interestingly, recent studies have progressively revealed GPER involvement in the maintenance of the normal immune system, abnormal immune diseases, and inflammatory lesions, which may be of significant clinical value primarily in the immunotherapy of tumors. In this article, we review current advances in GPER-related immunomodulators and provide a theoretical basis and potential clinical targets to ameliorate immune-related diseases and immunotherapy for tumors.
摘要：
雌激素和相关受体已被证明对人类发育有重大影响，繁殖，代谢和免疫调节，并在肿瘤的发展和治疗中发挥关键作用。传统上,核雌激素受体（nERs）ERα和ERβ被认为参与介导雌激素作用。然而,我们小组和其他人先前已经证明G蛋白偶联雌激素受体（GPER）是第三个独立的ER，已知GPER介导的雌激素信号在正常生理和多种异常疾病中起重要作用。有趣的是,最近的研究逐渐表明，GPER参与维持正常的免疫系统，免疫异常疾病，和炎性病变，这可能主要在肿瘤的免疫治疗中具有重要的临床价值。在这篇文章中,我们综述了GPER相关免疫调节剂的研究进展,为改善免疫相关疾病和肿瘤免疫治疗提供了理论依据和潜在的临床靶点.
