Abstract：
BACKGROUND: Essential tremor is a neurological condition associated with movement disorder with more prevalence among adult group of population. The burden of essential tremor is peaking globally but with the advancement in the area of functional neurosurgery such as stereotactic thalamotomy, the quality of life of such patients can be improved drastically.
METHODS: This systemic review was conducted in accordance to the guidance of preferred Reporting items for Systematic Review and Meta-Analysis(PRISMA). Databases of \"PubMed\", \"Embase\", \"Web of Science\", \"Cinhal Plus\", and \"Scopus\" from inception till 2023 was undertaken. A combination of keywords, Medical Subject Headings (MeSH), and search terms such as Search strategy for PubMed search was as follows: \"stereotactic thalamotomy\" AND \"essential tremor\".
RESULTS: This systematic review analyzed 9 studies with a total of 274 patients of essential tremor patients. Unilateral thalamotomy was carried out among 268 patients and bilateral thalamotomy in rest of the patients. Vim and Vom nucleus were the site of thalamotmy with ventral intermedius nucleus being the major one. Ten different types of clinical tremor rating scales were used to assess pre operative and post operative improvement in the tremor scales of the individual patients. Dysarthria and limb weakness was noted post operative complication in majority of the cases.
CONCLUSIONS: Our study revealed that stereotactic thalamotomy provided good functional outcome in patients of essential tremor who underwent unilateral thalamotomy compared to bilateral thalamotomy. The positive outcome outweighs the complications in such functional surgery.
METHODS: This systemic review was conducted in accordance to the guidance of preferred Reporting items for Systematic Review and Meta-Analysis(PRISMA). Databases of \"PubMed\", \"Embase\", \"Web of Science\", \"Cinhal Plus\", and \"Scopus\" from inception till 2023 was undertaken. A combination of keywords, Medical Subject Headings (MeSH), and search terms such as Search strategy for PubMed search was as follows: \"stereotactic thalamotomy\" AND \"essential tremor\".
RESULTS: This systematic review analyzed 9 studies with a total of 274 patients of essential tremor patients. Unilateral thalamotomy was carried out among 268 patients and bilateral thalamotomy in rest of the patients. Vim and Vom nucleus were the site of thalamotmy with ventral intermedius nucleus being the major one. Ten different types of clinical tremor rating scales were used to assess pre operative and post operative improvement in the tremor scales of the individual patients. Dysarthria and limb weakness was noted post operative complication in majority of the cases.
CONCLUSIONS: Our study revealed that stereotactic thalamotomy provided good functional outcome in patients of essential tremor who underwent unilateral thalamotomy compared to bilateral thalamotomy. The positive outcome outweighs the complications in such functional surgery.
摘要：
背景：原发性震颤是一种与运动障碍相关的神经系统疾病，在成年人群中患病率更高。原发性震颤的负担在全球范围内达到顶峰，但随着功能性神经外科领域的进步，如立体定向丘脑切开术，这些患者的生活质量可以大大提高。
方法：本系统评价是根据系统评价和荟萃分析（PRISMA）的首选报告项目指导进行的。\"PubMed\"的数据库,\"Embase\",\"WebofScience\",\"CinhalPlus\",和“Scopus”从成立到2023年。关键词的组合，医学主题词（MeSH），诸如PubMed搜索的搜索策略之类的搜索术语如下：“立体定向丘脑切开术”和“特发性震颤”。
结果：本系统综述分析了9项研究，共274例特发性震颤患者。268例患者进行了单侧丘脑切开术，其余患者进行了双侧丘脑切开术。Vim和Vom核是丘脑的部位，腹侧中间核是主要的。使用十种不同类型的临床震颤评定量表来评估个体患者的震颤量表的术前和术后改善。在大多数情况下，术后出现构音障碍和肢体无力。
结论：我们的研究表明，与双侧丘脑切开术相比，在单侧丘脑切开术的原发性震颤患者中，立体定向丘脑切开术提供了良好的功能结局。在这种功能性手术中，积极的结果胜过并发症。
方法：本系统评价是根据系统评价和荟萃分析（PRISMA）的首选报告项目指导进行的。\"PubMed\"的数据库,\"Embase\",\"WebofScience\",\"CinhalPlus\",和“Scopus”从成立到2023年。关键词的组合，医学主题词（MeSH），诸如PubMed搜索的搜索策略之类的搜索术语如下：“立体定向丘脑切开术”和“特发性震颤”。
结果：本系统综述分析了9项研究，共274例特发性震颤患者。268例患者进行了单侧丘脑切开术，其余患者进行了双侧丘脑切开术。Vim和Vom核是丘脑的部位，腹侧中间核是主要的。使用十种不同类型的临床震颤评定量表来评估个体患者的震颤量表的术前和术后改善。在大多数情况下，术后出现构音障碍和肢体无力。
结论：我们的研究表明，与双侧丘脑切开术相比，在单侧丘脑切开术的原发性震颤患者中，立体定向丘脑切开术提供了良好的功能结局。在这种功能性手术中，积极的结果胜过并发症。
