Abstract：
Nearly one fifth of patients with venous thromboembolism (VTE) have cancer. When both of these conditions occur, especially in cases of cerebral vein thrombosis (CVT), patient management is often challenging. The aim of this study was to compare the characteristics and event courses in patients affected by CVT with and without cancer. Consecutive patients with CVT from the ACTION-CVT cohort study were included if cancer status was reported. Risk factors as well as the clinical and radiological characteristics of patients were compared. Univariable and multivariable analyses were performed to assess variables associated with cancer. Kaplan-Meier method and log-rank test, logistic regression analysis, and propensity score matching were used to investigate any association between cancer-related CVT and study outcomes (primary outcome at 3-months: recurrent VTE or major hemorrhage; recurrent VTE; major hemorrhage; recanalization status; all-cause-death). Overall, 1,023 patients with CVT were included, of which 6.5% had cancer. Older age (adjusted odds ratio [aOR] 1.28 per decade increase; 95% confidence interval [CI] 1.08-1.52) and absence of headache (aOR 0.47; 95% CI 0.27-0.84) were independently associated with cancer. Patients with cancer had a higher risk of recurrent VTE or major hemorrhage (aOR 3.87; 95% CI 2.09-7.16), all-cause-death (aOR 7.56 95% CI 3.24-17.64), and major hemorrhage (aOR 3.70 95% CI 1.76-7.80). Recanalization rates, partial or complete, was not significantly different. CVT patients with cancer were more likely to be older, have no referred headache, and have worse outcomes compared to CVT patients without cancer.
摘要：
近五分之一的静脉血栓栓塞症（VTE）患者患有癌症。当这两种情况发生时，特别是在脑静脉血栓形成（CVT）的情况下，病人管理往往是具有挑战性的。这项研究的目的是比较患有和不患有癌症的CVT患者的特征和事件过程。如果报告了癌症状态，则包括ACTION-CVT队列研究中的连续CVT患者。比较了患者的危险因素以及临床和放射学特征。进行单变量和多变量分析以评估与癌症相关的变量。卡普兰-迈耶方法和对数秩检验，Logistic回归分析，和倾向评分匹配用于调查癌症相关CVT与研究结局(3个月时的主要结局:复发性VTE或大出血;复发性VTE;大出血;再通状态;全因死亡)之间的关联.总的来说,纳入了1,023例CVT患者，其中6.5%患有癌症。年龄较大（校正比值比[aOR]每十年增加1.28；95％置信区间[CI]1.08-1.52）和没有头痛（aOR0.47；95％CI0.27-0.84）与癌症独立相关。癌症患者发生VTE复发或大出血的风险较高(aOR3.87;95%CI2.09-7.16)。全因死亡（aOR7.5695%CI3.24-17.64），和大出血（aOR3.7095％CI1.76-7.80）。再化率，部分或完整，没有明显不同。患有癌症的CVT患者更有可能年龄较大，没有提到的头痛，与无癌症的CVT患者相比，预后更差。
