Abstract：
Modern medicine has increased the human lifespan. However, with an increase in average lifespan risk of amyloidosis increases. Amyloidosis is a condition characterized by protein misfolding and aggregation. Early detection of amyloidosis is crucial, yet conventional diagnostic methods are costly and lack precision, necessitating innovative tools. This review explores recent advancements in diverse amyloid detection methodologies, highlighting the need for interdisciplinary research to develop a miniaturized electrochemical biosensor leveraging nanotechnology. However, the diagnostics industry faces obstacles such as skilled labor shortages, standardized selection processes, and concurrent multi-analyte identification challenges. Research efforts are focused on integrating electrochemical techniques into clinical applications and diagnostics, with the successful transition of miniaturized technologies from development to testing posing a significant hurdle. Label-free transduction techniques like voltammetry and electrochemical impedance spectroscopy (EIS) have gained traction due to their rapid, cost-effective, and user-friendly nature.
摘要：
现代医学增加了人类的寿命。然而,随着平均寿命的增加，淀粉样变性的风险增加。淀粉样变是一种以蛋白质错误折叠和聚集为特征的病症。早期发现淀粉样变性至关重要，然而，传统的诊断方法既昂贵又缺乏准确性，需要创新工具。这篇综述探讨了各种淀粉样蛋白检测方法的最新进展，强调需要跨学科研究来开发一种利用纳米技术的小型化电化学生物传感器。然而,诊断行业面临诸如熟练劳动力短缺等障碍，标准化的选择过程，和并发的多分析物识别挑战。研究工作的重点是将电化学技术整合到临床应用和诊断中，随着小型化技术从开发到测试的成功过渡，这构成了一个重大障碍。伏安法和电化学阻抗谱（EIS）等无标记转导技术由于其快速，成本效益高,和用户友好的性质。
