Abstract：
The escalating global health concern arises from chronic wounds induced by bacterial infections, posing a significant threat to individuals. Consequently, an imperative exist for the development of hydrogel dressings to facilitate prompt wound monitoring and efficacious wound management. To this end, pH-sensitive bromothymol blue (BTB) and pH-responsive drug tetracycline hydrochloride (TH) were introduced into the polysaccharide-based hydrogel to realize the integration of wound monitoring and controlled treatment. Polysaccharide-based hydrogels were formed via a Schiff base reaction by cross-linking carboxymethyl chitosan (CMCS) on an oxidized sodium alginate (OSA) skeleton. BTB was used as a pH indicator to monitor wound infection through visual color changes visually. TH could be dynamically released through the pH response of the Schiff base bond to provide effective treatment and long-term antibacterial activity for chronically infected wounds. In addition, introducing polylactic acid nanofibers (PLA) enhanced the mechanical properties of hydrogels. The multifunctional hydrogel has excellent mechanical, self-healing, injectable, antibacterial properties and biocompatibility. Furthermore, the multifaceted hydrogel dressing under consideration exhibits noteworthy capabilities in fostering the healing process of chronically infected wounds. Consequently, the research contributes novel perspectives towards the advancement of intelligent and expeditious bacterial infection monitoring and dynamic treatment platforms.
摘要：
不断升级的全球健康问题源于细菌感染引起的慢性伤口，对个人构成重大威胁。因此,开发水凝胶敷料以促进及时的伤口监测和有效的伤口管理是当务之急。为此,将pH敏感型溴百里酚蓝(BTB)和pH响应型药物盐酸四环素(TH)引入多糖基水凝胶中,实现伤口监测与控制治疗的一体化。多糖基水凝胶是通过席夫碱反应通过在氧化海藻酸钠（OSA）骨架上交联羧甲基壳聚糖（CMCS）形成的。BTB用作pH指示剂,通过视觉颜色变化来监测伤口感染。TH可以通过席夫碱键的pH响应动态释放，为慢性感染的伤口提供有效的治疗和长期抗菌活性。此外,聚乳酸纳米纤维(PLA)的引入提高了水凝胶的力学性能。多功能水凝胶具有优异的机械性能，自我修复,可注射,抗菌性能和生物相容性。此外，正在考虑的多面水凝胶敷料在促进慢性感染伤口的愈合过程中表现出值得注意的能力。因此,这项研究为智能和快速的细菌感染监测和动态治疗平台的发展提供了新的视角。
