Abstract：
The integrated smart electronics for real-time monitoring and personalized therapy of disease-related analytes have been gradually gaining tremendous attention. However, human tissue barriers, including the skin barrier and brain-blood barrier, pose significant challenges for effective biomarker detection and drug delivery. Microneedle (MN) electronics present a promising solution to overcome these tissue barriers due to their semi-invasive structures, enabling effective drug delivery and target-analyte detection without compromising the tissue configuration. Furthermore, MNs can be fabricated through solution processing, facilitating large-scale manufacturing. This review provides a comprehensive summary of the recent three-year advancements in smart MNs development, categorized as follows. First, the solution-processed technology for MNs is introduced, with a focus on various printing technologies. Subsequently, smart MNs designed for sensing, drug delivery, and integrated systems combining diagnosis and treatment are separately summarized. Finally, the prospective and promising applications of next-generation MNs within mediated diagnosis and treatment systems are discussed.
摘要：
用于疾病相关分析物的实时监测和个性化治疗的集成智能电子设备已逐渐获得极大的关注。然而,人体组织屏障，包括皮肤屏障和脑血屏障,对有效的生物标志物检测和药物递送提出了重大挑战。微针（MN）电子学由于其半侵入性结构而提出了克服这些组织障碍的有希望的解决方案，实现有效的药物递送和目标分析物检测而不损害组织构造。此外，MNs可以通过溶液加工制造，促进大规模制造。这篇综述全面总结了最近三年智能MN开发的进展，分类如下。首先,介绍了MNs的溶液处理技术，专注于各种印刷技术。随后，设计用于传感的智能MN，药物输送,分别总结了诊断和治疗相结合的集成系统。最后,讨论了下一代MN在介导诊断和治疗系统中的前瞻性和有前途的应用。
