Abstract：
This study aimed to investigate the differences in clinical features, diagnostic examination, treatment, and pathological results between adult-onset and pediatric-onset tethered cord syndrome (TCS).
The authors searched the PubMed, Embase, and Cochrane Library databases through January 2023 for reports on TCS, extracting information on clinical features, imaging data, treatment modalities, prognosis, and pathological research results. A total of 6135 cases from 246 articles were included in the analysis. This review was conducted in accordance with the 2020 PRISMA guidelines and registered on PROSPERO.
The most common adult clinical manifestations were pain, urinary symptoms, and numbness; in children, they were urinary symptoms, skin lesions, bowel symptoms, and unspecific motor deficits. Surgical treatment was the primary approach for both adults and children, with a higher clinical improvement rate observed in adults. However, adults also had a higher rate of surgical complications than children. TCS pathological studies have not yet identified the differences between adults and children, and the pathogenesis of adult-onset TCS requires further investigation.
Adult-onset and pediatric-onset TCS exhibit certain differences in clinical characteristics, diagnostic examinations, and treatments. However, significant differences have not been found in current pathological studies between adults and children. Systematic review registration no.: CRD42023479450 (www.crd.york.ac.uk/prospero).
The authors searched the PubMed, Embase, and Cochrane Library databases through January 2023 for reports on TCS, extracting information on clinical features, imaging data, treatment modalities, prognosis, and pathological research results. A total of 6135 cases from 246 articles were included in the analysis. This review was conducted in accordance with the 2020 PRISMA guidelines and registered on PROSPERO.
The most common adult clinical manifestations were pain, urinary symptoms, and numbness; in children, they were urinary symptoms, skin lesions, bowel symptoms, and unspecific motor deficits. Surgical treatment was the primary approach for both adults and children, with a higher clinical improvement rate observed in adults. However, adults also had a higher rate of surgical complications than children. TCS pathological studies have not yet identified the differences between adults and children, and the pathogenesis of adult-onset TCS requires further investigation.
Adult-onset and pediatric-onset TCS exhibit certain differences in clinical characteristics, diagnostic examinations, and treatments. However, significant differences have not been found in current pathological studies between adults and children. Systematic review registration no.: CRD42023479450 (www.crd.york.ac.uk/prospero).
摘要：
目的：本研究旨在探讨临床特征的差异，诊断检查,治疗,和成人发作和儿童发作的脊髓栓系综合征（TCS）之间的病理结果。
方法：作者搜索了PubMed，Embase,和CochraneLibrary数据库到2023年1月，用于TCS报告，提取临床特征信息，成像数据,治疗方式，预后,和病理研究结果。分析共纳入246篇文献中的6135例。这项审查是根据2020年PRISMA指南进行的，并在PROSPERO上注册。
结果：成人最常见的临床表现是疼痛，泌尿症状,麻木；在儿童中，它们是泌尿症状，皮肤损伤,肠道症状,和非特异性运动缺陷。手术治疗是成人和儿童的主要方法，在成人中观察到更高的临床改善率。然而,成人的手术并发症发生率也高于儿童.TCS病理学研究尚未确定成人和儿童之间的差异，成人发病TCS的发病机制需要进一步研究。
结论：成人起病和儿童起病的TCS在临床特征上表现出一定的差异，诊断检查,和治疗。然而,在目前的病理研究中，成人和儿童之间没有发现显着差异。系统审查登记号。：CRD42023479450（www.crd.约克。AC.英国/普劳迪略）。
方法：作者搜索了PubMed，Embase,和CochraneLibrary数据库到2023年1月，用于TCS报告，提取临床特征信息，成像数据,治疗方式，预后,和病理研究结果。分析共纳入246篇文献中的6135例。这项审查是根据2020年PRISMA指南进行的，并在PROSPERO上注册。
结果：成人最常见的临床表现是疼痛，泌尿症状,麻木；在儿童中，它们是泌尿症状，皮肤损伤,肠道症状,和非特异性运动缺陷。手术治疗是成人和儿童的主要方法，在成人中观察到更高的临床改善率。然而,成人的手术并发症发生率也高于儿童.TCS病理学研究尚未确定成人和儿童之间的差异，成人发病TCS的发病机制需要进一步研究。
结论：成人起病和儿童起病的TCS在临床特征上表现出一定的差异，诊断检查,和治疗。然而,在目前的病理研究中，成人和儿童之间没有发现显着差异。系统审查登记号。：CRD42023479450（www.crd.约克。AC.英国/普劳迪略）。
