Abstract：
UNASSIGNED: Histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysine residues of histones and other proteins, generally leading to a closed chromosomal configuration and transcriptional repression. Different HDACs have distinct substrate specificities and functions in different biological processes. Accumulating evidence indicates that HDACs play a key role in the pathogenesis of multiple respiratory diseases.
UNASSIGNED: After an extensive search of the PubMed database, Web of Science and ClinicalTrials.gov, covering the period from 1992 to 2024, this review summarizes recent advances in understanding the role of HDACs in inflammatory respiratory diseases, including allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma and chronic obstructive pulmonary disease (COPD). We also examine recent progress on the efficacy and potential use of histone deacetylase inhibitors (HDACi) for the treatment of these diseases.
UNASSIGNED: Available data indicate that HDACs play an important role in the development of common inflammatory respiratory diseases, and HDACi have shown promise as treatments for these diseases. However, the exact roles and underlying mechanisms of specific HDACs in disease pathogenesis require further study. Additional work is necessary to develop novel potent HDACi with high isoform selectivity.
UNASSIGNED: After an extensive search of the PubMed database, Web of Science and ClinicalTrials.gov, covering the period from 1992 to 2024, this review summarizes recent advances in understanding the role of HDACs in inflammatory respiratory diseases, including allergic rhinitis (AR), chronic rhinosinusitis (CRS), asthma and chronic obstructive pulmonary disease (COPD). We also examine recent progress on the efficacy and potential use of histone deacetylase inhibitors (HDACi) for the treatment of these diseases.
UNASSIGNED: Available data indicate that HDACs play an important role in the development of common inflammatory respiratory diseases, and HDACi have shown promise as treatments for these diseases. However, the exact roles and underlying mechanisms of specific HDACs in disease pathogenesis require further study. Additional work is necessary to develop novel potent HDACi with high isoform selectivity.
摘要：
■组蛋白脱乙酰酶（HDAC）催化从组蛋白和其他蛋白质的赖氨酸残基中去除乙酰基，通常导致封闭的染色体构型和转录抑制。不同的HDAC在不同的生物过程中具有不同的底物特异性和功能。越来越多的证据表明，HDAC在多种呼吸系统疾病的发病机制中起着关键作用。
■在对PubMed数据库进行广泛搜索之后，WebofScienceandClinicalTrials.gov,这篇综述涵盖了1992年至2024年期间，总结了近年来在理解HDAC在炎症性呼吸系统疾病中的作用方面的进展，包括过敏性鼻炎（AR），慢性鼻-鼻窦炎(CRS),哮喘和慢性阻塞性肺疾病（COPD）。我们还研究了组蛋白去乙酰化酶抑制剂（HDACi）治疗这些疾病的功效和潜在用途的最新进展。
■现有数据表明，HDAC在常见炎症性呼吸道疾病的发展中起着重要作用，和HDACi已显示出有望治疗这些疾病。然而,特定HDACs在疾病发病机制中的确切作用和潜在机制需要进一步研究.需要额外的工作来开发具有高同工型选择性的新型有效HDACi。
■在对PubMed数据库进行广泛搜索之后，WebofScienceandClinicalTrials.gov,这篇综述涵盖了1992年至2024年期间，总结了近年来在理解HDAC在炎症性呼吸系统疾病中的作用方面的进展，包括过敏性鼻炎（AR），慢性鼻-鼻窦炎(CRS),哮喘和慢性阻塞性肺疾病（COPD）。我们还研究了组蛋白去乙酰化酶抑制剂（HDACi）治疗这些疾病的功效和潜在用途的最新进展。
■现有数据表明，HDAC在常见炎症性呼吸道疾病的发展中起着重要作用，和HDACi已显示出有望治疗这些疾病。然而,特定HDACs在疾病发病机制中的确切作用和潜在机制需要进一步研究.需要额外的工作来开发具有高同工型选择性的新型有效HDACi。
