Abstract：
MicroRNA (miRNA) are usually 18-25 nucleotides long non-coding RNA targeting post-transcriptional regulation of genes involved in various biological processes. The function of miRNA is essential for maintaining a homeostatic cellular condition, regulating autophagy, cellular motility, and inflammation. Dysregulation of miRNA is responsible for multiple disorders, including neurodegeneration, which has emerged as a severe problem in recent times and has verified itself as a life-threatening condition that can be understood by the continuous destruction of neurons affecting various cognitive and motor functions. Parkinson\'s disease (PD) is the second most common, permanently debilitating neurodegenerative disorder after Alzheimer\'s, mainly characterized by uncontrolled tremor, stiffness, bradykinesia or akinesia (slowness in movement), and post-traumatic stress disorder. PD is mainly caused by the demolition of the primary dopamine neurotransmitter secretory cells and dopaminergic or dopamine secretory neurons in the substantia nigra pars compacta of the midbrain, which are majorly responsible for motor functions. In this study, a systematic evaluation of research articles from year 2017 to 2022 was performed on multiple search engines, and lists of miRNA being dysregulated in PD in different body components were generated. This study highlighted miR-7, miR-124, miR-29 family, and miR-425, showing altered expression levels during PD\'s progression, further regulating the expression of multiple genes responsible for PD.
摘要：
MicroRNA(miRNA)通常是18-25个核苷酸长的非编码RNA,其靶向涉及各种生物过程的基因的转录后调控。miRNA的功能对于维持稳态细胞状况至关重要，调节自噬，细胞运动性,和炎症。miRNA的失调导致多种疾病，包括神经变性,最近出现了一个严重的问题，并证明了自己是一种危及生命的疾病，可以通过影响各种认知和运动功能的神经元的持续破坏来理解。帕金森病（PD）是第二常见的疾病，阿尔茨海默氏症后永久性衰弱的神经退行性疾病，主要表现为不受控制的震颤，刚度,运动迟缓或运动障碍（运动缓慢），和创伤后应激障碍。PD主要是由中脑黑质致密质中的初级多巴胺神经递质分泌细胞和多巴胺能或多巴胺分泌神经元的破坏引起的，主要负责运动功能。在这项研究中,在多个搜索引擎上对2017年至2022年的研究文章进行了系统评估，并产生了不同身体成分中PD失调的miRNA列表。这项研究强调了miR-7，miR-124，miR-29家族，和miR-425，显示在PD的进展过程中表达水平改变，进一步调节负责PD的多个基因的表达。
