Abstract：
Vascular remodeling is the adaptive response of the vessel wall to physiological and pathophysiological changes, closely linked to vascular diseases. Vascular smooth muscle cells (VSMCs) play a crucial role in this process. Pyroptosis, a form of programmed cell death characterized by excessive release of inflammatory factors, can cause phenotypic transformation of VSMCs, leading to their proliferation, migration, and calcification-all of which accelerate vascular remodeling. Inhibition of VSMC pyroptosis can delay this process. This review summarizes the impact of pyroptosis on VSMCs and the pathogenic role of VSMC pyroptosis in vascular remodeling. We also discuss inhibitors of key proteins in pyroptosis pathways and their effects on VSMC pyroptosis. These findings enhance our understanding of the pathogenesis of vascular remodeling and provide a foundation for the development of novel medications that target the control of VSMC pyroptosis as a potential treatment strategy for vascular diseases.
摘要：
血管重塑是血管壁对生理和病理生理变化的适应性反应，与血管疾病密切相关。血管平滑肌细胞(VSMC)在这一过程中起着至关重要的作用。焦亡,一种以过度释放炎症因子为特征的程序性细胞死亡形式，可引起VSMC的表型转化，导致它们的扩散，迁移,和钙化-所有这些加速血管重塑。抑制VSMC焦亡可以延迟该过程。本文综述了焦亡对VSMC的影响以及VSMC焦亡在血管重构中的致病作用。我们还讨论了焦亡途径中关键蛋白的抑制剂及其对VSMC焦亡的影响。这些发现增强了我们对血管重塑的发病机理的理解，并为开发靶向控制VSMC焦亡作为血管疾病潜在治疗策略的新型药物奠定了基础。
