Abstract：
Female Pattern Hair Loss (FPHL) is a common form of non-scaring hair loss that occurs in adult women. Although several treatments have already been proposed for FPHL, only Topical Minoxidil accumulated an adequate level of evidence. This study aimed to evaluate the therapeutic response of MMP® (intradermal infiltration) of Minoxidil formulation in the frontal-parietal-vertex regions compared with the gold-standard home administration of Minoxidil 5% Capillary Solution. This self-controlled comparative study evaluated 16 FPHL patients, without treatment for at least 6 months, confirmed by trichoscopy with TrichoLAB® software. They received 4 monthly sessions of MMP® with Minoxidil 0,5% on the right side of the scalp (frontal-parietal-vertex areas), followed by occlusion with plastic film for 12 h and prescription of Minoxidil 5% Solution for home use once a day, on both scalp sides, starting 72 h after the procedure. The reassessment trichoscopy was 6 weeks after the last session and they answered a \"self-assessment\" questionnaire. Treated scalp areas were compared and showed both treatments, in general, were effective, with no difference between them. If they were analyzed separately by treated areas, there were signs of better response in the parietal-vertex regions with treatment by MMP® with Minoxidil, while clinical treatment indicated a better response in the other regions. When patients were divided into more and less advanced cases, a better response in parietal-vertex regions treated by MMP® with Minoxidil in less advanced patients was confirmed. MMP® with Minoxidil showed a better response in the parietal-vertex regions in less advanced FPHL patients. It represents yet another resource to improve quality of life of these suffering patients.
摘要：
女性型脱发（FPHL）是成年女性中常见的非惊吓性脱发形式。尽管FPHL已经提出了几种治疗方法，只有局部米诺地尔积累了足够的证据。本研究旨在评估米诺地尔制剂在额-顶-顶点区域的MMP®(皮内浸润)与米诺地尔5%毛细管溶液的金标准家庭给药相比的治疗反应。这项自我对照的比较研究评估了16名FPHL患者，没有治疗至少6个月，通过使用TrichoLAB®软件的毛镜检查确认。他们在头皮右侧（额叶-顶叶-顶点区域）接受了4个月的MMP®治疗，其中米诺地尔0.5％，然后用塑料薄膜封闭12小时，每天一次使用米诺地尔5%溶液的处方，在头皮两侧，手术后72小时开始。在最后一次会议后6周进行了重新评估，他们回答了“自我评估”问卷。比较治疗的头皮区域，并显示两种治疗方法，总的来说,是有效的，它们之间没有区别。如果按治疗区域分别分析，用MMP®和米诺地尔治疗的顶叶-顶点区域有更好的反应迹象，而其他地区的临床治疗表明反应更好。当患者被分为更多和更少的晚期病例时，在晚期患者中,经MMP®联合米诺地尔治疗的顶叶-顶点区域的反应较好。在较不晚期的FPHL患者中,具有米诺地尔的MMP®在顶叶-顶点区域显示出更好的反应。它代表了改善这些痛苦患者生活质量的另一种资源。
