Abstract：
In this study, the correlation between pan-immune-inflammation value (PIV) and coronary collateral circulation (CCC) in patients with chronic coronary syndrome (CCS) was analyzed. The study included 663 patients with CCS who underwent coronary angiography and had coronary stenosis of ≥95% in at least one major coronary vessel. The participants were divided into two groups: good CCC (Rentrop score 2-3) and poor CCC (Rentrop score 0-1). PIV score was calculated as monocyte x platelet x neutrophil/lymphocyte count. When the patient groups who developed good and poor CCC were compared, neutrophil/lymphocyte ratio (NLR) (P < .001), C-reactive protein (CRP) levels, CRP/albumin ratio (CAR) (P < .001), systemic immune-inflammation index (SII) (P < .001), and PIV (P < .001) were higher in patients with poor CCC. In multivariate logistic regression analysis, age, SII, NLR, CRP, CAR, and PIV were found to be independent predictors of poor CCC (P < .001, for all). Receiver operating characteristic (ROC) analysis demonstrated that a cut-off value of 442.2 for PIV predicted poor CCC slightly better compared to other markers, with 76.8% sensitivity and 70.1% specificity (area under ROC curve = 0.808 (95% CI: 0.764-0.851), P < .001). These findings suggest that PIV can be used as an independent predictor of CCC development.
摘要：
在这项研究中,分析慢性冠脉综合征(CCS)患者泛免疫-炎症值(PIV)与冠脉侧支循环(CCC)的相关性.该研究包括663例CCS患者，这些患者接受了冠状动脉造影，并且至少有一条主要冠状动脉血管的冠状动脉狭窄≥95％。将参与者分为两组：良好的CCC（Rentrop评分2-3）和较差的CCC（Rentrop评分0-1）。PIV评分计算为单核细胞x血小板x中性粒细胞/淋巴细胞计数。当比较发展良好和不良CCC的患者组时，中性粒细胞/淋巴细胞比值（NLR）（P<.001），C反应蛋白(CRP)水平,CRP/白蛋白比值（CAR）（P<.001），全身免疫炎症指数（SII）（P<0.001），CCC较差患者的PIV和PIV（P<.001）较高。在多变量逻辑回归分析中，年龄,SII,NLR,CRP,汽车,和PIV被发现是不良CCC的独立预测因子(P<.001，全部)。接收器工作特性（ROC）分析表明，与其他标记物相比，PIV的截断值442.2预测不良CCC的效果略好，敏感性为76.8％，特异性为70.1％（ROC曲线下面积=0.808（95％CI：0.764-0.851），P<.001)。这些发现表明PIV可以用作CCC发展的独立预测因子。
