PDF(Pubmed)
Abstract：
Recent randomised controlled trials (RCTs) have investigated the analgesic activity of sesame oil among patients with limb trauma; nevertheless, their findings are inconsistent. Hence, this review aimed to clarify the impact of topical administration of sesame oil on acute pain of adult outpatients with minor limb trauma. The online databases (e.g., Scopus, PubMed, Web of Science) were searched up to 31 January 2024. The RCTs were included if they compared the effect of applying standard treatments plus topical sesame oil to administering standard treatments alone or with a placebo/sham treatment. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) and the Cochrane Collaboration\'s risk of bias tool were applied to address the evidence quality and the study\'s methodological rigour, respectively. Four RCTs had the inclusion criteria, and their findings were pooled in a meta-analysis employing a random-effects approach. According to the pooled analysis, the reduction in mean change of the pain score from baseline to the second/third intervention day was significantly higher in favour of clients who received standard care plus daily massage of the trauma site with sesame oil compared to those who received a control condition (weighted mean difference: -1.10; 95% confidence interval [-1.62, -0.57]; p < 0.001). However, the evidence quality was moderate, and only two studies had good methodological rigour. Hence, more high-quality studies are needed to make a solid evidence-based conclusion about the favourable consequence of topical sesame oil on alleviating acute traumatic limb pain.
摘要：
最近的随机对照试验（RCTs）研究了芝麻油在肢体创伤患者中的镇痛活性；然而，他们的发现是不一致的。因此，本综述旨在阐明芝麻油局部给药对成人肢体轻微创伤门诊患者急性疼痛的影响。在线数据库(例如，Scopus,PubMed,WebofScience）进行了搜索，截至2024年1月31日。如果将应用标准治疗加局部芝麻油与单独或与安慰剂/假治疗一起施用标准治疗的效果进行比较,则包括RCT。建议评估的分级，发展,和评估（等级）和Cochrane协作的偏倚工具的风险被用来解决证据质量和研究的方法学严谨，分别。四个随机对照试验有纳入标准，他们的研究结果汇集在一项采用随机效应方法的荟萃分析中.根据汇总分析，与接受对照条件的患者相比,疼痛评分从基线至第2/3干预日的平均变化降低显著高于接受标准护理和每日芝麻油按摩的患者(加权平均差异:-1.10;95%置信区间[-1.62,-0.57];p<0.001).然而,证据质量适中，只有两项研究方法严谨。因此，需要进行更多高质量的研究,以得出基于证据的确凿证据的结论,说明局部用芝麻油对缓解急性外伤性肢体疼痛的有利作用.
