关键词: B-cell lymphoma Fluorescence in situ hybridization Hodgkin lymphoma Molecular pathology Next generation sequencing T-cell lymphoma

Mesh : Humans Chromosome Aberrations Lymphoma / diagnosis genetics pathology

来  源:   DOI:10.1016/j.cll.2023.08.014

Abstract:
Lymphoid malignancies are a broad and heterogeneous group of neoplasms. In the past decade, the genetic landscape of these tumors has been explored and cataloged in fine detail offering a glimpse into the mechanisms of lymphomagenesis and new opportunities to translate these findings into patient management. A myriad of studies have demonstrated both distinctive and overlapping molecular and chromosomal abnormalities that have influenced the diagnosis and classification of lymphoma, disease prognosis, and treatment selection.
摘要:
淋巴恶性肿瘤是一类广泛且异质的肿瘤。在过去的十年里,我们已经对这些肿瘤的遗传前景进行了详细的探索和分类,这让我们了解了淋巴瘤发生的机制以及将这些发现转化为患者管理的新机会.大量研究表明,独特和重叠的分子和染色体异常影响了淋巴瘤的诊断和分类。疾病预后,和治疗选择。
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