Abstract：
Urothelial carcinoma is characterized by the presence of a wide spectrum of histopathologic features and molecular alterations that contribute to its morphologic and genomic heterogeneity. It typically harbors high rates of somatic mutations with considerable genomic and transcriptional complexity and heterogeneity that is reflective of its varied histomorphologic and clinical features. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of urothelial carcinoma and variant histologies.
摘要：
尿路上皮癌的特征是存在广泛的组织病理学特征和分子改变，这有助于其形态和基因组异质性。它通常具有高的体细胞突变率，具有相当大的基因组和转录复杂性和异质性，这反映了其不同的组织形态学和临床特征。这篇综述提供了关于尿路上皮癌和变异组织学的分子表征和新的分子分类学的最新进展。
