Abstract：
This study introduces a pH-responsive hydrogel developed from Delonix regia and mucin co-poly(acrylate) through free radical polymerization to enhance controlled drug delivery systems. Characterization using FTIR, DSC, TGA, SEM, PXRD, and EDX spectroscopy detailed the hydrogel\'s amorphous and crystalline structures, thermal stability, surface characteristics, and elemental composition. Tested at a pH of 7.4-mimicking intestinal conditions-the hydrogel demonstrated significant swelling, indicating its capability for targeted drug release. With Metformin HCl as a model drug, the hydrogel exhibited a promising sustained release profile, underscoring its potential for oral administration. Safety and biocompatibility were assessed through acute oral toxicity studies in albino rabbits, encompassing biochemical, hematological, and histopathological evaluations. X-ray imaging confirmed the hydrogel\'s navigability through the gastrointestinal tract, affirming its application in drug delivery. By potentially mitigating gastrointestinal side effects, enhancing patient compliance, and improving therapeutic efficacy, this Delonix regia/mucin co-poly(acrylate) hydrogel represents a step in pharmaceutical sciences, exploring innovative materials and methodologies for drug delivery.
摘要：
这项研究介绍了由Delonixregia和粘蛋白共聚（丙烯酸酯）通过自由基聚合开发的pH响应性水凝胶，以增强受控的药物递送系统。使用FTIR表征，DSC,TGA,SEM,PXRD,和EDX光谱详细说明了水凝胶的无定形和晶体结构，热稳定性，表面特性，和元素组成。在pH值为7.4的模拟肠道条件下进行测试-水凝胶显示出明显的溶胀，表明其靶向药物释放的能力。以盐酸二甲双胍为模型药物，水凝胶表现出有希望的持续释放曲线，强调其口服给药的潜力。通过白化病兔的急性口服毒性研究评估了安全性和生物相容性，包括生物化学，血液学,和组织病理学评估。X射线成像证实了水凝胶通过胃肠道的可导航性，肯定其在药物输送中的应用。通过减轻胃肠道副作用，提高患者依从性，提高治疗效果，这种Delonixregia/粘蛋白共-聚（丙烯酸酯）水凝胶代表了制药科学的一步，探索药物输送的创新材料和方法。
