Abstract：
BACKGROUND: Primary membranous nephropathy (PMN) patients may experience retinal microvascular changes. However, current diagnostic methods for PMN are not accurate in analyzing these modifications. In the present study, optical coherence tomography angiography (OCTA) was used for quantitative measurement of microvascular changes in the eyes of PMN patients.
METHODS: A total of 26 patients with PMN and 26 healthy control (HC) were evaluated in this cross-sectional study. Optical coherence tomography (OCT) and OCTA were used to collect retinal thickness (RT) and microvascular parameters in the macula and optic disk in the superficial capillary plexus (SCP) of all subjects. Clinical data were collected from the PMN group. The OCT and OCTA data for PMN and HC group were compared, and the correlation between the OCTA and clinical data in the PMN group was determined.
RESULTS: Vascular density (VD) and perfusion density (PD) in the macular area of the PMN group were significantly lower than those of the HC group, especially in the temporal quadrant. No significant difference in the foveal avascular zone (FAZ), optic disc microvascular parameters, RT, and retinal nerve fiber layer (RNFL) thickness was observed between the two groups. Correlation was noted between VD and PD in the macular area and clinical indicators, such as serum creatinine, serum urea nitrogen, 24 h urine volume and urinary protein concentration.
CONCLUSIONS: Microvascular alterations in PMN patients occurred before ocular symptoms. The present quantitative study proposed a measurement method for detecting early retinal vascular injury in PMN patients.
METHODS: A total of 26 patients with PMN and 26 healthy control (HC) were evaluated in this cross-sectional study. Optical coherence tomography (OCT) and OCTA were used to collect retinal thickness (RT) and microvascular parameters in the macula and optic disk in the superficial capillary plexus (SCP) of all subjects. Clinical data were collected from the PMN group. The OCT and OCTA data for PMN and HC group were compared, and the correlation between the OCTA and clinical data in the PMN group was determined.
RESULTS: Vascular density (VD) and perfusion density (PD) in the macular area of the PMN group were significantly lower than those of the HC group, especially in the temporal quadrant. No significant difference in the foveal avascular zone (FAZ), optic disc microvascular parameters, RT, and retinal nerve fiber layer (RNFL) thickness was observed between the two groups. Correlation was noted between VD and PD in the macular area and clinical indicators, such as serum creatinine, serum urea nitrogen, 24 h urine volume and urinary protein concentration.
CONCLUSIONS: Microvascular alterations in PMN patients occurred before ocular symptoms. The present quantitative study proposed a measurement method for detecting early retinal vascular injury in PMN patients.
摘要：
背景：原发性膜性肾病（PMN）患者可能会出现视网膜微血管改变。然而,当前的PMN诊断方法在分析这些修改时并不准确。在本研究中,光学相干断层扫描血管造影(OCTA)用于定量测量PMN患者眼睛的微血管变化.
方法：在这项横断面研究中，对26例PMN患者和26例健康对照（HC）患者进行了评估。光学相干断层扫描（OCT）和OCTA用于收集所有受试者浅表毛细血管丛（SCP）中黄斑和视盘的视网膜厚度（RT）和微血管参数。从PMN组收集临床数据。比较PMN和HC组的OCT和OCTA数据，并确定了PMN组OCTA与临床数据之间的相关性。
结果：PMN组黄斑区的血管密度（VD）和灌注密度（PD）明显低于HC组，尤其是在时间象限。在中央凹无血管区（FAZ）没有显着差异，视盘微血管参数，RT,观察两组视网膜神经纤维层(RNFL)厚度。黄斑区VD和PD与临床指标之间存在相关性，如血清肌酐，血清尿素氮，24小时尿量和尿蛋白浓度。
结论：PMN患者的微血管改变发生在眼部症状之前。本定量研究提出了一种检测PMN患者早期视网膜血管损伤的测量方法。
方法：在这项横断面研究中，对26例PMN患者和26例健康对照（HC）患者进行了评估。光学相干断层扫描（OCT）和OCTA用于收集所有受试者浅表毛细血管丛（SCP）中黄斑和视盘的视网膜厚度（RT）和微血管参数。从PMN组收集临床数据。比较PMN和HC组的OCT和OCTA数据，并确定了PMN组OCTA与临床数据之间的相关性。
结果：PMN组黄斑区的血管密度（VD）和灌注密度（PD）明显低于HC组，尤其是在时间象限。在中央凹无血管区（FAZ）没有显着差异，视盘微血管参数，RT,观察两组视网膜神经纤维层(RNFL)厚度。黄斑区VD和PD与临床指标之间存在相关性，如血清肌酐，血清尿素氮，24小时尿量和尿蛋白浓度。
结论：PMN患者的微血管改变发生在眼部症状之前。本定量研究提出了一种检测PMN患者早期视网膜血管损伤的测量方法。
