Abstract：
Neuropsychological studies report anxiety and depression like symptoms in patients suffering from lifestyle disorder but its impact on locomotor function lacks clarity. Our study investigates locomotor deficits resulting due to perturbations in cerebellum of high fat diet (HFD), chronodisruption (CD) or a combination (HCD) model of lifestyle disorder. Significant downregulation in levels of cerebellar clock genes (Bmal-1, Clock, Per 1 and Per 2) and Bdnf-Trkb pathway genes (Bdnf, TrkB and Syn1 levels) were recorded. Further, locomotor deficits were observed in all the three experimental groups as evidenced by actimeter test, pole test and wire hanging test. Nuclear pyknosis of Purkinje cells, their derangement and inflammation were the hallmark of cerebellar tissue of all the three experimental groups. Taken together, this study generates important links between cerebellar clock oscillations, locomotor function and Bdnf-TrkB signaling.
摘要：
神经心理学研究报告了患有生活方式障碍的患者的焦虑和抑郁症状，但其对运动功能的影响缺乏明确性。我们的研究调查了由于高脂肪饮食（HFD）的小脑扰动而导致的运动缺陷，生活方式障碍的时间中断（CD）或组合（HCD）模型。小脑时钟基因水平显著下调(Bmal-1，时钟，每1和每2）和Bdnf-Trkb途径基因（Bdnf，记录TrkB和Syn1水平）。Further,在所有三个实验组中都观察到运动缺陷，如通过活动计测试所证明的，电杆试验和挂线试验。浦肯野细胞的核固缩，他们的紊乱和炎症是所有三个实验组小脑组织的标志。一起来看,这项研究产生了小脑时钟振荡之间的重要联系，运动功能和Bdnf-TrkB信号传导。
