Abstract：
UNASSIGNED: To describe and compare clinical features, treatment approaches, and treatment outcomes of ocular tuberculosis (OTB) patients in the Netherlands, a low tuberculosis (TB)-endemic country, and Indonesia, a high TB-endemic country. We also aimed to identify predictors of treatment outcomes.
UNASSIGNED: A medical chart review of 339 OTB patients (n = 93 from the Netherlands and n = 246 from Indonesia) was performed. The primary outcome was response to treatment, whether with or without anti-tubercular treatment, after six months of treatment initiation (good versus poor responders).
UNASSIGNED: Indonesian OTB patients displayed a higher prevalence of chest radiograph findings indicative of TB infection (p < 0.001) and concurrent active systemic TB (p = 0.011). Indonesian cohort exhibited a more acute and severe disease profile, including uveitis duration ≤ 3 months (p < 0.001), blindness (p < 0.001), anterior chamber (AC) cells ≥ 2+ (p < 0.001), and posterior synechiae (p < 0.001). Overall proportions of good responders to treatment were 67.6% in the Netherlands and 71.5% in Indonesia. Presence of AC cell ≥ 2+ (adjusted odds ratio (aOR): 2.12, 95% CI: 1.09-4.14), choroidal lesions other than serpiginous-like choroiditis (SLC) or tuberculoma (aOR: 4.47, 95% CI: 1.18-16.90), and retinal vasculitis (aOR: 2.32, 95% CI: 1.10-4.90) at baseline were predictors for poor response to treatment.
UNASSIGNED: Despite a more severe initial clinical presentation in the Indonesian cohort, the overall treatment outcomes of OTB was comparable in both cohorts. Three baseline clinical features were identified as predictors of treatment outcomes.
UNASSIGNED: A medical chart review of 339 OTB patients (n = 93 from the Netherlands and n = 246 from Indonesia) was performed. The primary outcome was response to treatment, whether with or without anti-tubercular treatment, after six months of treatment initiation (good versus poor responders).
UNASSIGNED: Indonesian OTB patients displayed a higher prevalence of chest radiograph findings indicative of TB infection (p < 0.001) and concurrent active systemic TB (p = 0.011). Indonesian cohort exhibited a more acute and severe disease profile, including uveitis duration ≤ 3 months (p < 0.001), blindness (p < 0.001), anterior chamber (AC) cells ≥ 2+ (p < 0.001), and posterior synechiae (p < 0.001). Overall proportions of good responders to treatment were 67.6% in the Netherlands and 71.5% in Indonesia. Presence of AC cell ≥ 2+ (adjusted odds ratio (aOR): 2.12, 95% CI: 1.09-4.14), choroidal lesions other than serpiginous-like choroiditis (SLC) or tuberculoma (aOR: 4.47, 95% CI: 1.18-16.90), and retinal vasculitis (aOR: 2.32, 95% CI: 1.10-4.90) at baseline were predictors for poor response to treatment.
UNASSIGNED: Despite a more severe initial clinical presentation in the Indonesian cohort, the overall treatment outcomes of OTB was comparable in both cohorts. Three baseline clinical features were identified as predictors of treatment outcomes.
摘要：
■为了描述和比较临床特征，治疗方法,以及荷兰眼结核（OTB）患者的治疗结果，一个低结核病（TB）流行的国家，印度尼西亚,结核病流行率很高的国家。我们还旨在确定治疗结果的预测因素。
■对339例OTB患者（n=93来自荷兰，n=246来自印度尼西亚）进行了医学图表审查。主要结果是对治疗的反应，无论是否接受抗结核治疗，开始治疗6个月后（好与差的反应者）。
■印度尼西亚OTB患者的胸片表现出更高的患病率，表明TB感染（p<0.001）和并发活动性全身性TB（p=0.011）。印度尼西亚队列显示出更急性和更严重的疾病特征，包括葡萄膜炎持续时间≤3个月（p<0.001），失明（p<0.001），前房（AC）细胞≥2+（p<0.001），和后粘连（p<0.001）。在荷兰，对治疗的良好反应者的总体比例为67.6％，在印度尼西亚为71.5％。存在AC细胞≥2+（调整后比值比（AOR）：2.12，95％CI：1.09-4.14），脉络膜病变，而不是色素性脉络膜样脉络膜炎（SLC）或结核瘤（aOR：4.47，95％CI：1.18-16.90），和基线时的视网膜血管炎(aOR:2.32,95%CI:1.10-4.90)是治疗反应差的预测因子.
■尽管在印度尼西亚队列中出现了更严重的初始临床表现，OTB的总体治疗结局在两个队列中具有可比性.三个基线临床特征被确定为治疗结果的预测因子。
■对339例OTB患者（n=93来自荷兰，n=246来自印度尼西亚）进行了医学图表审查。主要结果是对治疗的反应，无论是否接受抗结核治疗，开始治疗6个月后（好与差的反应者）。
■印度尼西亚OTB患者的胸片表现出更高的患病率，表明TB感染（p<0.001）和并发活动性全身性TB（p=0.011）。印度尼西亚队列显示出更急性和更严重的疾病特征，包括葡萄膜炎持续时间≤3个月（p<0.001），失明（p<0.001），前房（AC）细胞≥2+（p<0.001），和后粘连（p<0.001）。在荷兰，对治疗的良好反应者的总体比例为67.6％，在印度尼西亚为71.5％。存在AC细胞≥2+（调整后比值比（AOR）：2.12，95％CI：1.09-4.14），脉络膜病变，而不是色素性脉络膜样脉络膜炎（SLC）或结核瘤（aOR：4.47，95％CI：1.18-16.90），和基线时的视网膜血管炎(aOR:2.32,95%CI:1.10-4.90)是治疗反应差的预测因子.
■尽管在印度尼西亚队列中出现了更严重的初始临床表现，OTB的总体治疗结局在两个队列中具有可比性.三个基线临床特征被确定为治疗结果的预测因子。
