Abstract：
OBJECTIVE: To overview the literature to answer the following question: \"What is the performance of different therapies on wound healing and postoperative discomfort after palatal ASTG removal?\"
METHODS: SRs that evaluated the wound healing (WH), postoperative pain, bleeding, and analgesic consumption of patients submitted to de-epithelialized/free gingival grafts (FGG) or subepithelial connective tissue grafts (SCTG) removed from the palate were included. The searches were conducted on six white and two gray databases up to December 2023. Methodological quality was evaluated through AMSTAR 2. The synthesis of results was described as a narrative analysis.
RESULTS: Ten SRs (involving 25 randomized clinical trials) related to low-level laser therapy (LLLT) (3), platelet-rich fibrin (PRF) (4), cyanoacrylate tissue adhesives (CTA) (2), and ozone therapy (OT) (1) were included in this overview. All techniques demonstrated improvements in WH. LLT, PRF, and CTA reduced pain and analgesic consumption. PRF and CTA reduced bleeding. Regarding methodological quality, the SRs were classified as critically low (2), low (5), moderate (2), or high quality (1).
CONCLUSIONS: In SRs related to LLLT, PRF, CTA, and OT, the use of different therapies after palatal ASTG removal improved WH and postoperative discomfort. Due to the studies\' low methodological quality and high heterogeneity, data should be interpreted with caution.
CONCLUSIONS: The present overview compiles the evidence of SRs related to different therapies for WH and patients\' postoperative experience and reveals that different treatments can significantly improve the clinical outcomes of patients who require ASTG removal for periodontal or peri-implant surgeries.
BACKGROUND: PROSPERO registration number: CRD42022301257.
METHODS: SRs that evaluated the wound healing (WH), postoperative pain, bleeding, and analgesic consumption of patients submitted to de-epithelialized/free gingival grafts (FGG) or subepithelial connective tissue grafts (SCTG) removed from the palate were included. The searches were conducted on six white and two gray databases up to December 2023. Methodological quality was evaluated through AMSTAR 2. The synthesis of results was described as a narrative analysis.
RESULTS: Ten SRs (involving 25 randomized clinical trials) related to low-level laser therapy (LLLT) (3), platelet-rich fibrin (PRF) (4), cyanoacrylate tissue adhesives (CTA) (2), and ozone therapy (OT) (1) were included in this overview. All techniques demonstrated improvements in WH. LLT, PRF, and CTA reduced pain and analgesic consumption. PRF and CTA reduced bleeding. Regarding methodological quality, the SRs were classified as critically low (2), low (5), moderate (2), or high quality (1).
CONCLUSIONS: In SRs related to LLLT, PRF, CTA, and OT, the use of different therapies after palatal ASTG removal improved WH and postoperative discomfort. Due to the studies\' low methodological quality and high heterogeneity, data should be interpreted with caution.
CONCLUSIONS: The present overview compiles the evidence of SRs related to different therapies for WH and patients\' postoperative experience and reveals that different treatments can significantly improve the clinical outcomes of patients who require ASTG removal for periodontal or peri-implant surgeries.
BACKGROUND: PROSPERO registration number: CRD42022301257.
摘要：
目的：综述文献以回答以下问题：“不同疗法对上颚ASTG去除后伤口愈合和术后不适的表现如何？”
方法：评估伤口愈合（WH）的SR，术后疼痛,出血,包括接受去上皮化/游离牙龈移植物（FGG）或上皮下结缔组织移植物（SCTG）的患者的镇痛消耗。截至2023年12月，搜索是在六个白色数据库和两个灰色数据库上进行的。通过AMSTAR2对方法学质量进行评价。结果的综合被描述为叙事分析。
结果：与低水平激光治疗（LLLT）相关的十个SR（涉及25项随机临床试验）（3），富血小板纤维蛋白(PRF)(4)，氰基丙烯酸酯组织粘合剂（CTA）（2），和臭氧治疗（OT）（1）包括在本概述中。所有技术都证明了WH的改进。LLT,PRF,和CTA减少疼痛和镇痛消耗。PRF和CTA减少出血。关于方法学质量，SR被归类为极低(2)，低（5），中等(2),或高质量（1）。
结论：在与LLLT相关的SR中，PRF,CTA,OT,使用不同的治疗方法后，在去除腭ASTG改善WH和术后不适。由于研究的方法学质量低，异质性高，数据应谨慎解释。
结论：本综述汇集了与WH的不同治疗方法和患者术后经验相关的SRs证据，并揭示了不同的治疗方法可以显著改善牙周或种植体周围手术需要去除ASTG的患者的临床结局。
背景：PROSPERO注册号：CRD42022301257。
方法：评估伤口愈合（WH）的SR，术后疼痛,出血,包括接受去上皮化/游离牙龈移植物（FGG）或上皮下结缔组织移植物（SCTG）的患者的镇痛消耗。截至2023年12月，搜索是在六个白色数据库和两个灰色数据库上进行的。通过AMSTAR2对方法学质量进行评价。结果的综合被描述为叙事分析。
结果：与低水平激光治疗（LLLT）相关的十个SR（涉及25项随机临床试验）（3），富血小板纤维蛋白(PRF)(4)，氰基丙烯酸酯组织粘合剂（CTA）（2），和臭氧治疗（OT）（1）包括在本概述中。所有技术都证明了WH的改进。LLT,PRF,和CTA减少疼痛和镇痛消耗。PRF和CTA减少出血。关于方法学质量，SR被归类为极低(2)，低（5），中等(2),或高质量（1）。
结论：在与LLLT相关的SR中，PRF,CTA,OT,使用不同的治疗方法后，在去除腭ASTG改善WH和术后不适。由于研究的方法学质量低，异质性高，数据应谨慎解释。
结论：本综述汇集了与WH的不同治疗方法和患者术后经验相关的SRs证据，并揭示了不同的治疗方法可以显著改善牙周或种植体周围手术需要去除ASTG的患者的临床结局。
背景：PROSPERO注册号：CRD42022301257。
