Abstract：
BACKGROUND: The purpose of this study was to describe taking, timing, and dosing adherence to home caregiver-administered intravenous (IV) immunosuppressants in a sample of pediatric hematopoietic stem cell transplant (HCT) recipients.
METHODS: Sixteen children who had undergone HCT, ages 3 months to 15 years, and their caregivers participated. All caregivers were biological mothers. Caregivers completed a demographic questionnaire as part of a larger study and brought in portable infusion pumps to download the pump data at the time of their child\'s post-HCT clinic visit. Pump data were then examined for dose taking, timing, and amount for 30 days following discharge.
RESULTS: Despite the importance of the precise timing of IV immunosuppressants, adherence taking, dosing, and timing varied widely in this sample. The mean percentage of doses administered was 98.72%, and 81.3% of children received all doses of immunosuppressant. However, only 62% of doses were given on time and the mean difference between the prescribed and actual administration time was 67.03 minutes.
CONCLUSIONS: Although taking adherence was high, the timing and dosing adherence to IV immunosuppressants in the home was poor. Additional support to promote adherence should be provided including assisting caregivers to identify and use adherence strategies specific to their child\'s IV immunosuppressant regimen in the home.
METHODS: Sixteen children who had undergone HCT, ages 3 months to 15 years, and their caregivers participated. All caregivers were biological mothers. Caregivers completed a demographic questionnaire as part of a larger study and brought in portable infusion pumps to download the pump data at the time of their child\'s post-HCT clinic visit. Pump data were then examined for dose taking, timing, and amount for 30 days following discharge.
RESULTS: Despite the importance of the precise timing of IV immunosuppressants, adherence taking, dosing, and timing varied widely in this sample. The mean percentage of doses administered was 98.72%, and 81.3% of children received all doses of immunosuppressant. However, only 62% of doses were given on time and the mean difference between the prescribed and actual administration time was 67.03 minutes.
CONCLUSIONS: Although taking adherence was high, the timing and dosing adherence to IV immunosuppressants in the home was poor. Additional support to promote adherence should be provided including assisting caregivers to identify and use adherence strategies specific to their child\'s IV immunosuppressant regimen in the home.
摘要：
背景：这项研究的目的是描述服用，定时,以及在儿科造血干细胞移植（HCT）接受者的样本中，对家庭护理人员给予的静脉（IV）免疫抑制剂的给药依从性。
方法：16名接受过HCT的儿童，年龄3个月到15岁，和他们的照顾者参与。所有照顾者都是亲生母亲。作为一项大型研究的一部分，看护者完成了一份人口统计问卷，并在其孩子在HCT后就诊时引入便携式输液泵下载泵数据。然后检查泵的剂量数据，定时,以及出院后30天的金额。
结果：尽管静脉注射免疫抑制剂的精确时机很重要，坚持服用，给药,在这个样本中，时间差异很大。给药剂量的平均百分比为98.72％，81.3%的儿童接受了所有剂量的免疫抑制剂。然而,只有62%的剂量按时给药,处方给药时间与实际给药时间的平均差为67.03分钟.
结论：虽然服药依从性高，在家庭中,静脉注射免疫抑制剂的时间和给药依从性较差.应提供额外的支持，以促进依从性，包括协助看护者确定和使用家庭中针对其子女的IV免疫抑制剂方案的依从性策略。
方法：16名接受过HCT的儿童，年龄3个月到15岁，和他们的照顾者参与。所有照顾者都是亲生母亲。作为一项大型研究的一部分，看护者完成了一份人口统计问卷，并在其孩子在HCT后就诊时引入便携式输液泵下载泵数据。然后检查泵的剂量数据，定时,以及出院后30天的金额。
结果：尽管静脉注射免疫抑制剂的精确时机很重要，坚持服用，给药,在这个样本中，时间差异很大。给药剂量的平均百分比为98.72％，81.3%的儿童接受了所有剂量的免疫抑制剂。然而,只有62%的剂量按时给药,处方给药时间与实际给药时间的平均差为67.03分钟.
结论：虽然服药依从性高，在家庭中,静脉注射免疫抑制剂的时间和给药依从性较差.应提供额外的支持，以促进依从性，包括协助看护者确定和使用家庭中针对其子女的IV免疫抑制剂方案的依从性策略。
